Comparing Oral Melatonin and Nebulized Dexmedetomidine to Reduce Agitation After Adenotonsillectomy in Children Ages 3 to 7

What this Trial Is About

This research aims to compare the effects of oral melatonin versus nebulized dexmedetomidine in reducing emergence agitation in children aged 3 to 7 years undergoing adenotonsillectomy, a common surgery with a high risk of agitation and pain after anesthesia. The study evaluates these treatments to find better ways to manage anxiety and pain during recovery in pediatric patients. It is a prospective, randomized controlled trial sponsored by Tanta University. Participants are randomly assigned to one of three groups one receiving a placebo nebulizer with midazolam in apple juice, another receiving oral melatonin syrup with a placebo nebulizer, and the third receiving nebulized dexmedetomidine with placebo syrup. These treatments are given before surgery to study their effects on emergence agitation and related symptoms. The trial uses a double-blind design to ensure unbiased results. Children involved in the study will be assessed for emergence agitation within 30 minutes after recovery. Additional evaluations include perioperative anxiety during transfer to the operating room, mask tolerance during surgery, pain levels, and postoperative analgesic use up to 6 hours after surgery. Researchers monitor these outcomes alongside safety data during the trial period, which runs from July 2025 to July 2027.

Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy