Actively Recruiting
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
Led by Ohio State University Comprehensive Cancer Center · Updated on 2025-06-22
1000
Participants Needed
1
Research Sites
185 weeks
Total Duration
On this page
Sponsors
O
Ohio State University Comprehensive Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia. The lung and oral cancers that plague Appalachia are fueled by cigarette smoking. Oral nicotine pouches which contain nicotine but no tobacco leaf, present a new opportunity to reduce cancer risk among Appalachian adults who smoke. Oral nicotine pouches and nicotine replacement therapy may work well to reduce cigarette use for smokers in rural Appalachia.
CONDITIONS
Official Title
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Read and speak English
- 21 years or older
- Smoke at least 5 cigarettes per day for the past year
- Willing to use Oral Nicotine Pouches or Nicotine Replacement Therapy
- Live in a rural Appalachian County
- Have a smartphone or willing to use one for the study
- Willing to blow air into a handheld study device
- If able to become pregnant, confirm not pregnant by urine pregnancy test
You will not qualify if you...
- Currently using smoking cessation medications, nicotine replacement therapy, or actively seeking smoking cessation treatment
- Used oral nicotine pouches in the past 3 months
- Used nicotine replacement therapies in the past 3 months
- Use other tobacco products more than 10 days per month
- Have unstable or significant medical conditions
- Have unstable or significant psychiatric conditions (stable past conditions allowed)
- Had a cardiac event or distress within the past 3 months
- Live in the same household as another study participant
- Currently pregnant, planning pregnancy within 6 months, or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
T
The Ohio State University Comprehensive Cancer Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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