Actively Recruiting
Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D
Led by Research Center of Periodontal-Systemic Interactions · Updated on 2026-03-25
25
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
Sponsors
R
Research Center of Periodontal-Systemic Interactions
Lead Sponsor
U
University of Medicine and Pharmacy Craiova
Collaborating Sponsor
AI-Summary
What this Trial Is About
Periodontal disease is a chronic inflammatory condition associated with systemic diseases, highlighting the concept of periodontal medicine. This study aims to investigate the relationship between periodontal inflammation, oral lesions, and hepatitis B+D infection, with or without bulevirtide treatment. Oral-periodontal clinical parameters and targeted inflammatory biomarkers in saliva and gingival crevicular fluid will be evaluated in three groups: patients with hepatitis B+D receiving bulevirtide, patients with hepatitis B+D not receiving bulevirtide, and healthy controls.
CONDITIONS
Official Title
Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults (≥18 years old) capable of providing informed consent
- Confirmed co-infection with hepatitis B and D for hepatitis B+D groups
- Receiving bulevirtide therapy for the bulevirtide group
- Not receiving bulevirtide for the no bulevirtide group
- Systemically healthy adults without hepatitis B or D infection for the healthy control group
- Willingness to undergo oral-periodontal exams, saliva and gingival fluid collection, and oral photography
You will not qualify if you...
- Presence of other systemic diseases affecting periodontal health (e.g., uncontrolled diabetes, autoimmune diseases)
- Receiving other experimental therapies that may affect oral or systemic inflammation
- Pregnancy or lactation
- Inability or unwillingness to provide informed consent
- History of oral or periodontal surgery within the last 6 months affecting measurements
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Clinical Emergency County Hospital Craiova
Craiova, Romania
Actively Recruiting
2
University of Medicine and Pharmacy of Craiova
Craiova, Romania
Actively Recruiting
Research Team
P
Petra Surlin, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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