Actively Recruiting
Effect of Oral Glutamine Supplement on Adults With Gastric Cancer After Gastrectomy Surgery
Led by National Taiwan University Hospital · Updated on 2025-12-23
120
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying the effects of oral glutamine supplementation on patients with gastric adenocarcinoma who undergo gastrectomy. The main goal is to assess how glutamine impacts sarcopenia, a condition involving muscle loss, in these patients. Secondary goals include evaluating changes in physical activity, weight loss, and nutritional status during recovery. This double-blind, randomized, placebo-controlled trial will enroll at least 80 patients scheduled for gastrectomy. Participants will be divided into two groups one receiving 10 grams of glutamine plus 5 grams of maltodextrin daily for 28 days after surgery, and the other receiving 15 grams of maltodextrin as a placebo for the same period. Both groups will take the supplements orally or via enteral feeding as tolerated. Before surgery and 90 days after, CT scans will measure muscle area changes. Patients will wear smartwatches to track daily walking steps, and laboratory tests including serum albumin, pre-albumin, white blood cell, and lymphocyte counts will be conducted before surgery and 90 days postoperatively. The main outcome is the change in psoas muscle area 84 days after surgery. Participants physical activity, weight, and nutritional markers will also be monitored throughout the study.
CONDITIONS
Brief Title
Oral Supplementation of Glutamine on Gastric Cancer Patients After Gastrectomy
Research Team
J
Jin-Ming Wu, MD
M
Ming-Tsan Lin, MD
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