Actively Recruiting
Oral Supplementation of Glutamine on Gastric Cancer Patients After Gastrectomy
Led by National Taiwan University Hospital · Updated on 2025-12-23
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of oral glutamine supplementation on patients with gastric adenocarcinoma who undergo gastrectomy. The main goal is to assess how glutamine impacts sarcopenia, a condition involving muscle loss, in these patients. Secondary goals include evaluating changes in physical activity, weight loss, and nutritional status during recovery. This double-blind, randomized, placebo-controlled trial will enroll at least 80 patients scheduled for gastrectomy. Participants will be divided into two groups: one receiving 10 grams of glutamine plus 5 grams of maltodextrin daily for 28 days after surgery, and the other receiving 15 grams of maltodextrin as a placebo for the same period. Both groups will take the supplements orally or via enteral feeding as tolerated. Before surgery and 90 days after, CT scans will measure muscle area changes. Patients will wear smartwatches to track daily walking steps, and laboratory tests including serum albumin, pre-albumin, white blood cell, and lymphocyte counts will be conducted before surgery and 90 days postoperatively. The main outcome is the change in psoas muscle area 84 days after surgery. Participants' physical activity, weight, and nutritional markers will also be monitored throughout the study.
CONDITIONS
Brief Title
Oral Supplementation of Glutamine on Gastric Cancer Patients After Gastrectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult gastric cancer patients scheduled for gastrectomy
You will not qualify if you...
- Hepatic insufficiency
- Renal insufficiency
- Inability to tolerate oral or enteral feeding 7 days after gastrectomy
- Unable to receive computed tomography (CT) scans
- Unable to wear wearable devices such as smartwatches
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 28 days
Participants receive oral supplementation of glutamine or placebo for 28 days after gastrectomy while tolerating oral intake or enteral feeding.
Visits occur during the 28-day supplementation period
Duration - Up to 90 days after surgery
Participants are monitored with CT scans and laboratory tests before surgery and on postoperative day 90, and wear a smartwatch to record daily walking steps.
Visits on pre-surgery, and postoperative day 90
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan, 100
Actively Recruiting
Research Team
J
Jin-Ming Wu, MD
M
Ming-Tsan Lin, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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