Actively Recruiting
Oral Versus Intravenous Fluid Therapy in the Emergency Department
Led by Esbjerg Hospital - University Hospital of Southern Denmark · Updated on 2026-01-23
250
Participants Needed
3
Research Sites
38 weeks
Total Duration
On this page
Sponsors
E
Esbjerg Hospital - University Hospital of Southern Denmark
Lead Sponsor
O
Odense University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this randomized clinical feasibility trial is to determine whether oral fluid therapy can achieve prescribed fluid volumes as effectively as intravenous fluid therapy in adult patients admitted to the emergency department who require fluid treatment. The main questions it aims to answer are: Are patients receiving oral fluids equally likely to achieve the prescribed fluid volume compared with patients receiving intravenous fluids? Is it feasible to conduct a randomized trial of oral versus intravenous fluid therapy in the emergency department, based on recruitment rate and protocol adherence? Researchers will compare oral tap water administration with standard intravenous crystalloid therapy to assess whether oral fluids are non-inferior in achieving prescribed fluid volumes and to evaluate feasibility outcomes. Participants will: Be randomized to receive either oral tap water or intravenous crystalloid fluids during their stay in the emergency department Receive a fluid volume and administration rate determined by the treating physician Be monitored according to standard clinical practice during the emergency department stay Have fluid intake, vital signs, and clinical outcomes recorded, with follow-up through routine health records up to 30 days after inclusion
CONDITIONS
Official Title
Oral Versus Intravenous Fluid Therapy in the Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or above
- At least 1000 ml of crystalloid fluid therapy prescribed by the physician
You will not qualify if you...
- Altered mental state preventing oral fluid intake (Glasgow Coma Scale 64 12)
- Pregnancy
- Oral fluids contraindicated (e.g. bowel obstruction)
- Severe hyponatremia (sodium <120 mEq/L)
- Requiring treatment in the intensive care unit
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Emergency Department, South Jutland Hospital
Aabenraa, Denmark
Actively Recruiting
2
Emergency Department, Esbjerg Hospital
Esbjerg, Denmark, 6700
Actively Recruiting
3
Odense University Hospital
Odense, Denmark, 5000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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