Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07361952

Oral Versus Intravenous Fluid Therapy in the Emergency Department

Led by Esbjerg Hospital - University Hospital of Southern Denmark · Updated on 2026-01-23

250

Participants Needed

3

Research Sites

38 weeks

Total Duration

On this page

Sponsors

E

Esbjerg Hospital - University Hospital of Southern Denmark

Lead Sponsor

O

Odense University Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this randomized clinical feasibility trial is to determine whether oral fluid therapy can achieve prescribed fluid volumes as effectively as intravenous fluid therapy in adult patients admitted to the emergency department who require fluid treatment. The main questions it aims to answer are: Are patients receiving oral fluids equally likely to achieve the prescribed fluid volume compared with patients receiving intravenous fluids? Is it feasible to conduct a randomized trial of oral versus intravenous fluid therapy in the emergency department, based on recruitment rate and protocol adherence? Researchers will compare oral tap water administration with standard intravenous crystalloid therapy to assess whether oral fluids are non-inferior in achieving prescribed fluid volumes and to evaluate feasibility outcomes. Participants will: Be randomized to receive either oral tap water or intravenous crystalloid fluids during their stay in the emergency department Receive a fluid volume and administration rate determined by the treating physician Be monitored according to standard clinical practice during the emergency department stay Have fluid intake, vital signs, and clinical outcomes recorded, with follow-up through routine health records up to 30 days after inclusion

CONDITIONS

Official Title

Oral Versus Intravenous Fluid Therapy in the Emergency Department

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 or above
  • At least 1000 ml of crystalloid fluid therapy prescribed by the physician
Not Eligible

You will not qualify if you...

  • Altered mental state preventing oral fluid intake (Glasgow Coma Scale 64 12)
  • Pregnancy
  • Oral fluids contraindicated (e.g. bowel obstruction)
  • Severe hyponatremia (sodium <120 mEq/L)
  • Requiring treatment in the intensive care unit

AI-Screening

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Trial Site Locations

Total: 3 locations

1

Emergency Department, South Jutland Hospital

Aabenraa, Denmark

Actively Recruiting

2

Emergency Department, Esbjerg Hospital

Esbjerg, Denmark, 6700

Actively Recruiting

3

Odense University Hospital

Odense, Denmark, 5000

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Oral Versus Intravenous Fluid Therapy in the Emergency Department | DecenTrialz