Actively Recruiting
Oral Vitamin D3 Effect on Inflammatory Biomarkers in Ulcerative Colitis Patients
Led by University of Veterinary and Animal Sciences, Lahore - Pakistan · Updated on 2025-12-17
60
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial aims to evaluate the effect of oral vitamin D3 supplementation on inflammatory biomarkers and disease activity in Pakistani patients with moderate ulcerative colitis. Sixty patients will be randomized to receive either standard treatment alone/Placebo or standard treatment plus vitamin D3 (50,000 IU fortnightly) for 12 weeks. Primary outcomes include changes in blood (CRP, ESR, IL-6) and fecal (calprotectin) inflammatory biomarkers, and disease activity assessed by the partial Mayo score. Secondary outcomes include vitamin D status, dietary intake, and quality of life. The study will provide insights into the immune-modulating and anti-inflammatory role of vitamin D3 as an adjunct therapy in ulcerative colitis.
CONDITIONS
Official Title
Oral Vitamin D3 Effect on Inflammatory Biomarkers in Ulcerative Colitis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients previously diagnosed with moderate ulcerative colitis by standard clinical and colonoscopic criteria
- Both male and female patients
- No change in type or dosage of medication in the past month
- Severe vitamin D deficiency (less than 10 ng/mL) after screening
- Age between 20 and 40 years
- Written informed consent provided
You will not qualify if you...
- Use of vitamin D supplements within 3 months before the study
- Diagnosis of Crohn's disease or any other autoimmune disease
- Mild or severe ulcerative colitis
- Changes in medication type or dosage during the study
- Pregnancy or lactation
- Known kidney disease
- Known liver disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Veterinary & Animal Sciences, Lahore
Lahore, Punjab Province, Pakistan, 54000
Actively Recruiting
Research Team
M
Muhammad Barkaat Azam, PhD Scholar
CONTACT
D
Dr. Qaisar Raza, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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