Actively Recruiting
Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
Led by The University of Texas Health Science Center, Houston · Updated on 2025-09-05
20
Participants Needed
1
Research Sites
131 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the effects of suvorexant (SUVO), on sleep, stress, and drug craving during early abstinence from stimulants and to determine the effects of treatment (SUVO vs. treatment as usual (TAU)) on post-treatment (Days 13-30) residential program length of stay (LOS) and completion rate.
CONDITIONS
Official Title
Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for primary stimulant use disorder (either cocaine or methamphetamine)
- Be fluent in English and able to understand the consent form
- Be between 18 and 65 years old
You will not qualify if you...
- Have an opioid use disorder of any severity
- Have a greater than moderate substance use disorder on any other substance
- Undergoing medication-assisted treatment for withdrawal of any substance
- Have medical conditions contraindicating suvorexant including severe pulmonary or cardiovascular disease, abnormal ECG, severe liver or kidney disease, seizure disorder, or sleep disorders such as narcolepsy
- Currently taking medications with known interactions with suvorexant such as MAO inhibitors, anticonvulsants, haloperidol, phenothiazines, anesthetics, or sedatives
- Are pregnant or breastfeeding
- Women with body mass index greater than 30
- Have a current DSM-5 psychiatric or neurological disorder requiring ongoing treatment that would make participation unsafe
- Have a history of seizure disorder
- Have had a head injury with loss of consciousness in the last 5 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
H
Heather Webber, PhD
CONTACT
J
Jessica Vincent
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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