Actively Recruiting
Organoid-guided Personalized Treatment of Pleural Effusion
Led by Henan Cancer Hospital · Updated on 2025-05-06
20
Participants Needed
1
Research Sites
97 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is a single-arm, single-center clinical research that utilizes patient-derived tumor organoids to predict drug sensitivity, thereby assisting clinicians in formulating treatment plans to benefit lung cancer patients with pleural effusion. This study is divided into three parts: acquisition of clinical samples from patients, in vitro organoid culture and drug sensitivity testing, and correlation of organoid sensitivity results with clinical medication guidance. Researchers obtained pre-treatment tissue samples and provided them to Suzhou Xianjue Biotechnology Co., Ltd. to establish organoid models. Once established, drug incubation was performed for sensitivity testing. Subsequently, treatment for malignant pleural effusion was guided based on drug sensitivity data.
CONDITIONS
Official Title
Organoid-guided Personalized Treatment of Pleural Effusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Able to understand and voluntarily sign informed consent
- Good compliance and ability to cooperate with diagnosis and follow-up
- ECOG performance status score of 0 to 2
- Presence of malignant pleural effusion
- At least one measurable lesion as assessed by the investigator
You will not qualify if you...
- History of malignant tumor within the past 5 years
- Serious complications such as uncontrolled heart disease, severe arrhythmia needing treatment, or persistent watery diarrhea
- Pregnant or lactating female patients
- Patients considered unsuitable for participation by the study team
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Henan cancer hospital
Zhengzhou, Henan, China, 475000
Actively Recruiting
Research Team
Q
Qiming Wang
CONTACT
S
Sen Yang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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