Actively Recruiting
Organoid Models of Hepatocellular Carcinoma
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-09-15
150
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns and can be used to test the susceptibility of a specific tumour to anticancer agents. In this study, PDOs for HCC will be developed that closely resemble the tumour microenvironment in vivo and mimic the crosstalk of the gut-liver axis to establish a correlation with patient prognosis and test the efficacy of available systemic therapies.
CONDITIONS
Official Title
Organoid Models of Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent
- Age 18 years or older
- Suspected radiological diagnosis of hepatocellular carcinoma or diagnosed with hepatocellular carcinoma with indications for surgical removal
You will not qualify if you...
- Age under 18 years
- Contraindications to liver biopsy such as ascites, platelet count below 50,000, or INR above 1.7
- Contraindications to surgical removal of hepatocellular carcinoma
- Active viral infection
- Refusal to provide informed consent for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC CEMAD, Largo A. Gemelli, 8
Roma, Italy, 00168
Actively Recruiting
Research Team
F
Francesca Romana Ponziani, PI
CONTACT
E
Elisabetta Creta, SC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here