Actively Recruiting
Organoids From Breast Cancer Patients Treated With Neoadjuvant Therapy
Led by Istituti Clinici Scientifici Maugeri SpA · Updated on 2025-12-03
240
Participants Needed
1
Research Sites
144 weeks
Total Duration
On this page
Sponsors
I
Istituti Clinici Scientifici Maugeri SpA
Lead Sponsor
A
ASST Fatebenefratelli Sacco
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to establish patient-derived organoid (PDO) and tumor tissue cultures from breast cancer patients, in order to create personalized, accurate, and reliable preclinical models capable of providing information on the diverse biomolecular portraits of breast cancer. These models may also be used to predict the achievement of pathological complete response after neoadjuvant chemotherapy (NAC) treatment, study the biological, molecular, genetic, and microenvironmental characteristics of each tumor, and isolate tumor-derived extracellular vesicles from the PDOs and tissues and analyze them as potential biomarkers of response to NAC.
CONDITIONS
Official Title
Organoids From Breast Cancer Patients Treated With Neoadjuvant Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female subjects
- Confirmed diagnosis of breast heteroplasia
- Age 18 years or older
- Indication for neoadjuvant chemotherapy
- Patients willing to follow the usual oncological follow-up
- Patients with de novo metastatic disease receiving primary chemotherapy if candidates for primary tumor biopsy
- Subjects who agree to participate by signing the informed consent form
You will not qualify if you...
- Patients who have already undergone prior chemotherapy treatments
- Patients without a proven cyto-histological diagnosis of breast carcinoma
- Subjects affected by other solid tumors besides the breast lesion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Istituti Clinici Scientifici Maugeri
Pavia, PV, Italy, 27100
Actively Recruiting
Research Team
F
Fabio CorsI
CONTACT
M
Marta Truffi
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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