Actively Recruiting
Oriental Intervention for Enhanced Neurocognitive Health (Orient) Diet in Populations With High Risk of Stroke (ENDS)
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2025-06-15
160
Participants Needed
1
Research Sites
138 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial will enroll 160 individuals aged over 40 without dementia who are at high risk of stroke, collecting multi-modal MRI imaging, serum, and fecal samples to investigate the impact of the ORIENT diet on brain functional networks.
CONDITIONS
Official Title
Oriental Intervention for Enhanced Neurocognitive Health (Orient) Diet in Populations With High Risk of Stroke (ENDS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 240 years or older
- High risk of stroke with three or more of the following risk factors: hypertension, dyslipidemia, diabetes, atrial fibrillation or valvular heart disease, smoking history, obvious overweight or obesity, lack of exercise, family history of stroke, or history of transient ischemic attack
- Written informed consent provided
- Willingness to complete all assessments and follow-up participation
- Adequate vision and hearing to complete neuropsychological testing
You will not qualify if you...
- Allergies to nuts, berries, olive oil, or fish
- Previous diagnosis of dementia
- Suspected dementia after clinical assessment at screening
- Previous major head trauma or any intracranial surgery
- Intracranial abnormalities such as hemorrhages or space occupying lesions
- Extrapyramidal symptoms or mental illness affecting neuropsychological testing
- Severe loss of vision, hearing, or communication ability
- Malignant disease with life expectancy less than 3 years
- Participation in another investigational drug study
- Any contraindications for MRI
- Poor adherence, inability to comply with follow-up, or safety concerns during the study
- Any adverse or serious adverse events during the study as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Second Affilated Hospital of Zhejiang University, School of Medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
Research Team
M
Min Lou, PhD, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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