Actively Recruiting
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Led by University of Edinburgh · Updated on 2025-12-02
120
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
U
University of Edinburgh
Lead Sponsor
B
British Heart Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Ischaemic stroke is usually due to occlusion of a cerebral artery by thrombus. However, it is often difficult to identify the source of thrombus, or to confirm thrombus as a cause of ischaemic stroke. Moreover, it is debated whether thrombosis plays any role in certain types of stroke such as lacunar stroke. In preliminary studies, the investigators have evaluated a novel clinical grade thrombus-specific radiotracer, 18F-GP1, which has a high specificity for the glycoprotein IIb/IIIa receptor on activated platelets. The investigations have demonstrated that 18F-GP1 is highly sensitive to in vivo thrombus formation and demonstrates avid binding to thrombus associated with myocardial infarction, pulmonary embolism and aortic bioprosthesis. This study will use this imaging approach to define the role and origin of thrombus in patients with ischaemic stroke, cryptogenic stroke and lacunar stroke.The investigators will also assess its added clinical value in assessing patients with ischaemic stroke.
CONDITIONS
Official Title
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 18 years old and above
- Diagnosis of acute ischaemic stroke within 21 days of symptom onset according to American Heart and Stroke Association guidelines
You will not qualify if you...
- Inability or unwillingness to provide informed written consent
- Inability to undergo scanning protocol including transfer onto the scanner
- Women of child-bearing potential if pregnancy cannot be excluded
- Contraindication to PET-CT scanning including estimated glomerular filtration rate less than 30 mL/min/1.73 m2
- Participation would delay carotid endarterectomy surgery
- Known allergy to iodinated contrast or radiotracer
- Severe or significant comorbidity preventing completion of study procedures
- Haemorrhagic stroke
- Contraindication to magnetic resonance imaging for patients needing MRI head
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Clinical Research Facility
Edinburgh, United Kingdom
Actively Recruiting
Research Team
B
Beth Whittington, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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