Actively Recruiting

Age: 18Years +
All Genders
ID05636748

The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke

Led by University of Edinburgh · Updated on 2025-12-02

120

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

U

University of Edinburgh

Lead Sponsor

B

British Heart Foundation

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are investigating the role and origin of thrombus in patients with ischaemic stroke, cryptogenic stroke, and lacunar stroke. The study evaluates a new imaging method using the radiotracer 18F-GP1, which specifically binds to activated platelets involved in thrombus formation. This imaging aims to improve understanding of stroke causes, especially in cases where the source of the clot is unclear or debated, such as cryptogenic and lacunar strokes. Participants will undergo diagnostic imaging including one 18F-GP1 PET/CT scan to detect platelet activation in thrombi. Additional assessments may include an agitated contrast echocardiogram to check for heart-related sources of clots, MRI of the head if needed, and ECG monitoring for up to 7 days to detect irregular heart rhythms. These tests will help identify the location and contribution of activated platelets to the stroke. Throughout the study, participants will be evaluated within 21 days of stroke symptom onset. Researchers will measure the degree and location of platelet activation using the PET/CT scans and correlate findings with other clinical and imaging data. The study includes close monitoring of participants during imaging and heart rhythm assessments to better define stroke mechanisms and potentially influence future patient management.

CONDITIONS

Brief Title

The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Males and females 18 years old or older
  • Diagnosis of acute ischaemic stroke within 21 days of symptom onset as per guidelines
Not Eligible

You will not qualify if you...

  • Unable or unwilling to provide informed written consent
  • Unable to undergo scanning protocol or transfer onto scanner
  • Women of child-bearing potential with unknown pregnancy status
  • Contraindication to PET-CT scanning including low kidney function (eGFR <30 mL/min/1.73 m2)
  • Participation would delay carotid endarterectomy surgery
  • Known allergy to iodinated contrast or radiotracer
  • Severe comorbidity preventing completion of study procedures
  • Haemorrhagic stroke
  • Contraindication to MRI for those requiring MRI head scan

AI-Screening

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Your Study Journey

Screening

Duration - Up to 3 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Up to 3 weeks

Participants undergo diagnostic imaging and assessments to identify the origin and presence of activated platelets in thromboembolism related to ischaemic stroke.

1 to 4 visits including PET/CT scan, echocardiogram, ECG monitoring, and possibly MRI head scan depending on clinical need

Long-term Monitoring

Duration - Up to 3 weeks

Participants are observed to understand the frequency and distribution of activated platelets in different stroke subtypes and their clinical features.

Follow-up assessments as needed within the 3-week period

Trial Site Locations

Total: 1 location

1

Clinical Research Facility

Edinburgh, United Kingdom

Actively Recruiting

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Research Team

B

Beth Whittington, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010.

Rita V Krishnamurthi, Valery L Feigin, Mohammad H Forouzanfar...

https://pubmed.ncbi.nlm.nih.gov/25104492

Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study.

Linxin Li, Gabriel S Yiin, Olivia C Geraghty...

https://pubmed.ncbi.nlm.nih.gov/26227434

Glycoprotein IIb/IIIa receptor imaging with 18F-GP1 positron emission tomography for acute venous thromboembolism: an open-label, non-randomized, first-in-human phase 1 study.

Chanwoo Kim, Jae Seung Lee, Youngjin Han...

https://pubmed.ncbi.nlm.nih.gov/29959214