Study to Identify Biomarkers in HPV-Related and Other Oropharyngeal Cancers Observational Study with Blood and Saliva Sample Collection

What this Trial Is About

Researchers are studying oropharyngeal squamous cell carcinoma caused by human papillomavirus HPV to find biomarkers that indicate when the disease is present or absent. This observational study aims to identify markers found at diagnosis or recurrence but not after treatment, in HPV-negative patients, or in healthy controls. The goal is to improve diagnosis and understanding of this cancer type. Participants will provide blood and saliva samples, complete questionnaires, and allow review of their medical records. The study does not involve treatment but observes patients over time to collect data. There is an active monitoring phase requiring at least two follow-up visits in person, including one pre-treatment visit, to track biomarker changes and disease status. During the study, researchers will measure changes in biomarkers, genetic alterations, and immunologic markers related to diagnosis and prognosis up to 24 months. Participants will be involved in sample collections and questionnaires. The study monitors oncologic outcomes associated with biomarkers and collects data through medical record reviews. Participation lasts up to two years, with ongoing evaluation of health and biomarker status.

Oropharynx (OPX) Biomarker Trial