Actively Recruiting
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Led by VA Office of Research and Development · Updated on 2025-11-03
194
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more severe than outpatient settings. Obstructive sleep apnea (OSA) is highly comorbid with both disorders and untreated OSA is associated with worse functional impairment across multiple domains, worse quality of life, worse PTSD, higher suicidal ideation, and higher substance use and relapse rates. Treating OSA with evidence-based positive airway pressure (PAP) in Veterans with SUD/PTSD on a residential unit is a logical way to maximize treatment adherence and treatment outcomes. This study compares OSA treatment while on a SUD/PTSD residential unit to a waitlist control group. The investigators hypothesize that treating OSA on the residential unit, compared to the waitlist control, will have better functional, SUD, and PTSD outcomes.
CONDITIONS
Official Title
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be a Veteran of the U.S. military or Reserve/National Guard member
- Be at least 18 years of age
- Have an apnea-hypopnea index (AHI) of 5 or more per hour
- Experienced trauma in childhood or adulthood, with at least one month since the trauma
- Have a current DSM-5 diagnosis of substance use disorder with at least 20 days of substance use in the last 90 days
- Have a full PTSD diagnosis confirmed by clinician-administered PTSD scale
- Be literate in English
- Be on the PTSD track of the SARRTP residential unit
- Be capable of giving informed consent
You will not qualify if you...
- Have central sleep apnea with an AHI of 5 or more and over 50% central apneas
- Already be using a PAP device upon arrival at the SARRTP unit
- Be advised against participation by SARRTP medical staff based on medical history or physical exam
- Have a history of severe cognitive impairment (Montreal Cognitive Assessment score below 26)
- Have a history of psychosis or mania independent of substance use
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161-0002
Actively Recruiting
Research Team
P
Peter Colvonen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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