Actively Recruiting
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Led by St. Anne's University Hospital Brno, Czech Republic · Updated on 2026-04-27
100
Participants Needed
1
Research Sites
430 weeks
Total Duration
On this page
Sponsors
S
St. Anne's University Hospital Brno, Czech Republic
Lead Sponsor
M
Masaryk University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure. Remote ischemic preconditioning (short periods of ischemia in anticipation of longer period of ischemia) may act protectively against ischemia. Studies of ischemic preconditioning in patients with AAA are conflicting. Obstructive sleep apnea (OSA) is a sleep disordered breathing syndrome which may have a protective effect against ischemia. The investigators hypothesize that I/R injury will be less pronounced in patients who have OSA and that the extent of I/R injury will inversely correlate with OSA severity. Accordingly, the aim of this study is to compare postoperative complications and markers of I/R in patients undergoing elective AAA repair who do and do not have OSA.
CONDITIONS
Official Title
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for elective aorto-bifemoral bypass surgery for AAA or Leriche syndrome
You will not qualify if you...
- Emergent surgery
- Aorto-bifemoral bypass using deep vein graft
- Re-operations
- Known obstructive sleep apnea with CPAP treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Anne's University Hospital Brno
Brno, Czech Republic, Czechia, 65691
Actively Recruiting
Research Team
I
Ivan Cundrle, M.D., Ph.D.
CONTACT
M
Marek Lukes, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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