Obstructive Sleep Apnea as Remote Ischemic Preconditioning in Patients Scheduled for Aorto-bifemoral Bypass Surgery

What this Trial Is About

This research aims to evaluate the impact of obstructive sleep apnea (OSA) as a possible protective factor against ischemia and reperfusion (I/R) injury during elective abdominal aortic aneurysm (AAA) repair and aorto-bifemoral bypass surgery. The study investigates whether patients with OSA experience less I/R injury and fewer postoperative complications compared to those without OSA. The relationship between OSA severity and I/R injury is also examined to understand if greater OSA severity corresponds to reduced injury. Participants scheduled for elective aorto-bifemoral bypass surgery, including those with AAA and Leriche syndrome, will be observed. Polygraphy sleep studies using the Embletta system will be conducted two nights before surgery, alongside STOP-BANG and Epworth questionnaires to assess OSA. Patients are grouped based on OSA status (presence or absence) and undergo the standard surgical procedure without additional interventions. During the study, markers of I/R injury will be measured at multiple time points: before anesthesia, and at 3, 12, 24 hours, and on the fifth postoperative day after aorta de-clamping. Cardiovascular and pulmonary complications will be monitored for 30 days after surgery. These assessments aim to track the extent of I/R injury and related complications to better understand the protective role of OSA in vascular surgery. The total study period extends to 30 days post-operation with detailed outcome evaluations.

OSA as a Remote Ischemic Preconditioning in Vascular Surgery