Study of Obstructive Sleep Apneas Protective Role During Elective Aorto-Bifemoral Bypass Surgery

What this Trial Is About

This research aims to evaluate the impact of obstructive sleep apnea OSA as a possible protective factor against ischemia and reperfusion IR injury during elective abdominal aortic aneurysm AAA repair and aorto-bifemoral bypass surgery. The study investigates whether patients with OSA experience less IR injury and fewer postoperative complications compared to those without OSA. The relationship between OSA severity and IR injury is also examined to understand if greater OSA severity corresponds to reduced injury. Participants scheduled for elective aorto-bifemoral bypass surgery, including those with AAA and Leriche syndrome, will be observed. Polygraphy sleep studies using the Embletta system will be conducted two nights before surgery, alongside STOP-BANG and Epworth questionnaires to assess OSA. Patients are grouped based on OSA status presence or absence and undergo the standard surgical procedure without additional interventions. During the study, markers of IR injury will be measured at multiple time points before anesthesia, and at 3, 12, 24 hours, and on the fifth postoperative day after aorta de-clamping. Cardiovascular and pulmonary complications will be monitored for 30 days after surgery. These assessments aim to track the extent of IR injury and related complications to better understand the protective role of OSA in vascular surgery. The total study period extends to 30 days post-operation with detailed outcome evaluations.

OSA as a Remote Ischemic Preconditioning in Vascular Surgery