Actively Recruiting
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
Led by Xuanwu Hospital, Beijing · Updated on 2025-03-04
124
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective multi-center observational study is to learn about the osmotic therapy in severe subarachnoid hemorrhage (SAH). The main question\[s\] it aims to answer are: • whether the two osmotic therapy, 20% mannitol and 10% hypertonic saline(HTS), under the same osmotic equivalent, has similar influence on the outcome of SAH patients? Participants will be given proper treatment according to local expert consensus, including the choice of osmotic medicine. Investigators just record and analyse the data, compare mannitol group and HTS group to see if the outcome of latter is not worse than the former.
CONDITIONS
Official Title
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of aneurysmal subarachnoid hemorrhage
- Hunt-Hess grade between 3 and 5
You will not qualify if you...
- Previous cranial decompression surgery or cerebrospinal fluid leakage or drainage
- Bilateral pupils fixed or dilated
- Hemodynamic instability
- Hemoglobin less than 8 g/L
- Serum osmolality greater than 320 mOsm/L
- Severe organ dysfunction (cardiac, pulmonary, hepatic, renal, etc.)
- Serious electrolyte disorders (serum sodium less than 125 mmol/L or greater than 170 mmol/L) that are difficult to correct quickly
- Serious acid-base balance disorders difficult to correct quickly
- Use of mannitol or hypertonic saline within the previous six hours
- Being pregnant
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Xuanwu Hospital
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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