Actively Recruiting
Osteosarcopenia in Axial Spondyloarthritis
Led by Ankara University · Updated on 2024-08-29
97
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Axial spondyloarthritis is a chronic inflammatory disease affecting the spine, sacroiliac joints, entheses, and sometimes peripheral joints with a close link to HLAB27. Typical features include inflammatory back pain, limited spinal mobility, and sacroiliitis. The term axial spondyloarthritis (AxSpA) includes both Ankylosing Spondylitis (AS) where sacroiliitis is diagnosed by X-rays, and non-radiographic AxSpA, where sacroiliitis is diagnosed via magnetic resonance imaging (MRI). Osteoporosis is common in AS patients, and sarcopenia may also develop due to inflammation and immobilization. Osteosarcopenia, the co-occurrence of osteoporosis and sarcopenia, might have an impact on morbidity and mortality of AxSpA patients. This cross-sectional study aims to determine the frequency of osteosarcopenia in AxSpA patients and to investigate its relationship with various demographic and clinical factors. A control group with similar age and gender distribution will be recruited to evaluate osteosarcopenia. Our hypothesis is that osteosarcopenia will be more frequent in the AxSpA group compared to the control group. The study will also identify the demographic and clinical factors associated with osteosarcopenia in AxSpa.
CONDITIONS
Official Title
Osteosarcopenia in Axial Spondyloarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants diagnosed with axial spondyloarthritis, including Ankylosing Spondylitis or non-radiographic Spondyloarthritis
- Age between 18 and 65 years
- Provided consent to participate in the study
- Healthy control participants matched by age and gender (18-65 years)
- Provided consent to participate in the study
You will not qualify if you...
- Use of systemic high-dose steroids (more than 5 mg/day prednisone for over 3 months)
- Presence of other causes of secondary sarcopenia such as uncontrolled diabetes, chronic heart failure, thyroid or parathyroid disease, chronic kidney or liver failure
- Hand disorders affecting grip strength assessment
- Use of medications that affect bone metabolism like bisphosphonates, teriparatide, anticonvulsants, heparin, or anticoagulants
- Diagnosis of psoriasis or inflammatory bowel disease
- Infection in the thigh area planned for ultrasonographic evaluation
- Body weight over 100 kg (not suitable for bone mineral density device)
- Malnutrition indicated by a Mini Nutritional Assessment-Short Form score of 11 or below
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ankara University Hospitals, Department of Physical Medicine and Rehabilitation
Ankara, Turkey (Türkiye), 06230
Actively Recruiting
Research Team
A
Ayşe A Küçükdeveci, MD
CONTACT
İ
İsmail Aksu, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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