Full pulpotomy versus root canal therapy in mature teeth with irreversible pulpitis: a randomized controlled trial.
Lina Zhu, Wei Liu, Xuetao Deng...
https://pubmed.ncbi.nlm.nih.gov/39415163Actively Recruiting
Led by Mustafa Kemal University · Updated on 2026-06-05
99
Participants Needed
1
Research Sites
17 weeks
Total Duration
Researchers are evaluating the clinical effectiveness of total pulpotomy, radicular pulpotomy, and root canal treatment in mandibular premolar and molar teeth diagnosed with symptomatic irreversible pulpitis. The study aims to compare these treatments in terms of postoperative pain control and treatment success over time. A total of 99 teeth will be included and randomly assigned to one of the three treatment groups to assess outcomes using standardized protocols. The study involves three treatment groups: total pulpotomy, radicular pulpotomy, and root canal treatment. Total pulpotomy consists of removing the coronal pulp and applying mineral trioxide aggregate (MTA) after achieving hemostasis. Radicular pulpotomy involves removing pulp tissue a few millimeters below the canal orifices, followed by MTA application. Root canal treatment includes cleaning and shaping of the root canals with irrigation and obturation using a calcium silicate-based sealer. All treated teeth will receive a final restoration with glass ionomer cement and composite resin. Participants will receive local anesthesia and undergo treatment according to their assigned group. Postoperative pain will be recorded using a visual analog scale at specified times up to 7 days after treatment. Clinical and radiographic evaluations to assess treatment success and periapical health will occur at 3, 6, and 12 months. Additional assessments include restorative integrity and pulp sensibility testing. Patients will be monitored for up to one year, with measures of pain and healing recorded as primary outcomes.
CONDITIONS
Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment visit
Participants receive one of three dental treatments: total pulpotomy, radicular pulpotomy, or root canal treatment. Procedures include local anesthesia, caries removal, pulp tissue removal or root canal instrumentation, application of materials for pulp protection or canal obturation, and final tooth restoration. Postoperative pain management instructions are provided.
1 visit (in-person)
Duration - Up to 12 months
Participants return for clinical and radiographic evaluations at 3, 6, and 12 months to assess treatment success, including pain assessment, pulp sensibility tests, and restorative integrity checks. Additional visits may occur earlier if symptoms arise.
3 visits (in-person) at 3, 6, and 12 months, with additional visits as needed
Total: 1 location
1
Department of Endodontics, Faculty of Dentistry, Hatay Mustafa Kemal University
Hatay, Antakya, Turkey (Türkiye), 31000
Actively Recruiting
E
Efkan Aksay
M
Merve Sarı, DDS
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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