Actively Recruiting
Outcomes of the Suspension Uretheroileal Technique During Open Radical Cystectomy and Ileal Neobladder Surgery A Prospective Randomized Comparative Study
Led by Sohag University · Updated on 2025-01-22
60
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates the outcomes of a suspension uretheroileal technique during open radical cystectomy and ileal neobladder reconstruction. The study compares this technique with the conventional method to evaluate differences in continence rates at 1, 3, 6, and 12 months after the procedure. The condition being studied is radical cystectomy, often performed for muscle-invasive or certain high-grade non-muscle-invasive bladder carcinomas in patients aged 18 to 80 years. The suspension uretheroileal technique involves ligating the complex of the dorsal vein complex and puboprostatic ligaments, sharply dividing it from the prostate, and then reconstructing the ileal pouch by everting the mucosa and suturing it outward. The neobladder neck is narrowed to about 1 cm to allow passage of a 20 F catheter. Anastomotic sutures are placed at specific clock positions through the full thickness of the urethra. The key difference in the suspension technique is that two sutures are anchored to the ligated complex to suspend the poucho-urethral anastomosis, unlike the conventional approach. Participants will be monitored over 12 months to assess continence outcomes at multiple time points following surgery. The study includes detailed surgical procedures, and researchers will evaluate the success of the suspension technique compared to the conventional method. The total participation involves follow-up visits to measure urinary continence and assess recovery progress, ensuring careful observation of patient outcomes after the procedure.
CONDITIONS
Official Title
Outcomes of Uretheroileal Suspension Technique During Open Radical Cystectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient age >18 years
- Diagnosis of muscle-invasive bladder carcinoma (MIBC)
- Diagnosis of non-muscle-invasive bladder carcinoma (NMIBC) with recurrent disease unresponsive to treatment
- High-grade tumors (T1, carcinoma in situ) refractory to intravesical therapy
- Multifocal or recurrent high-grade tumors despite intravesical therapy
- Tumor progression from NMIBC to MIBC
You will not qualify if you...
- Non-muscle-invasive bladder carcinoma (NMIBC) or benign disease not meeting inclusion
- Severe liver or kidney dysfunction
- Urethral involvement with bladder carcinoma
- Poor overall health status
- Severe kidney dysfunction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sohag University Hospital
Sohag, Egypt
Actively Recruiting
Research Team
A
abdelrahman m abdellah, assistant lecturer
A
ahmed m mohamed, lecturer
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here