Actively Recruiting
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Led by Washington University School of Medicine · Updated on 2026-05-07
10
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
V
Varian Medical Systems
Collaborating Sponsor
AI-Summary
What this Trial Is About
Female patients with early onset (\<50 years old) pelvic malignancies such as uterine and rectal cancers are rising in incidence, which often requires pelvic radiation; many of these patients are premenopausal and at a high risk of premature ovarian failure from radiotherapy. Premature ovarian failure carries significant cardiac, musculoskeletal, sexual, and psychosocial morbidity. Ovarian transposition carries variable success rates, is not readily accessible to the general population, and can still be at risk of clinically significant radiotherapy doses. There is an unmet need for innovative techniques to protect ovarian function.
CONDITIONS
Official Title
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biologic female
- Age between 18 and 50 years old (inclusive)
- Clinically premenopausal with active, regular menstruation and no vasomotor symptoms
- At least one ovary clearly visible on diagnostic CT or MRI as confirmed by a radiologist
- Planning to receive radiation therapy for any reason
- Able to understand and willing to sign informed consent
You will not qualify if you...
- Prior pelvic radiation therapy
- Previous cancer treatments known to affect ovarian function
- Prior diagnosis of ovarian insufficiency, ovarian failure, or menopause
- Clinically peri- or post-menopausal status
- For patients over 45, history of menopause symptoms or irregular periods excludes participation
- For patients 45 or younger, menopause symptoms, irregular menstruation for 3 or more months, or recent menstrual changes over 14 days exclude participation
- Surgically removed or transposed ovaries
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
M
Michael Waters, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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