Ovarian Tissue Cryopreservation Combined With Oocyte Cryopreservation Versus Oocyte Cryopreservation Alone: an Observational Study in Oncology Patients

What this Trial Is About

This research aims to evaluate fertility preservation methods for female cancer patients who will undergo treatments that may harm their ovarian reserve, such as chemotherapy, radiotherapy, or surgery. The study compares two approaches: ovarian tissue cryopreservation combined with oocyte cryopreservation versus oocyte cryopreservation alone, to better understand how to protect fertility before gonadotoxic therapy. Participants will be divided into two groups based on their planned cancer treatment and available time before therapy starts. One group will undergo ovarian tissue freezing followed by egg freezing, while the other group will have only egg freezing. The study collects data from both retrospective and prospective participants over a period of more than four years. During the study, researchers will monitor the number of eggs retrieved, the rate of egg retrieval compared to follicles aspirated, mature egg counts, and the occurrence of moderate ovarian hyperstimulation syndrome after retrieval. Blood hormone levels will also be analyzed to see their relation to egg yield. Safety events such as infections or internal bleeding will be tracked. Participation involves monitoring before and after egg retrieval, with total enrollment lasting several years.

Ovarian Tissue Cryopreservation Combined With Oocyte Cryopreservation Versus Oocyte Cryopreservation Alone