Actively Recruiting
Overcoming Nicotine Dependence to Enable Quitting
Led by Rush University Medical Center · Updated on 2025-08-17
780
Participants Needed
1
Research Sites
231 weeks
Total Duration
On this page
Sponsors
R
Rush University Medical Center
Lead Sponsor
M
Medical University of South Carolina
Collaborating Sponsor
AI-Summary
What this Trial Is About
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.
CONDITIONS
Official Title
Overcoming Nicotine Dependence to Enable Quitting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years or older
- Currently smoke at least 5 cigarettes daily
- Not planning to quit smoking in the next 30 days
- Not currently receiving smoking cessation treatment
- Motivated to quit or reduce smoking, learn about treatment options, or try skills to change smoking within 6 months
- Able to speak English
- Reside in the continental United States
- Have access to a smartphone to complete study procedures
You will not qualify if you...
- Use electronic cigarettes daily on 25 or more days in the past 30 days
- Pregnant or breastfeeding
- Recent cardiovascular trauma such as myocardial infarction
- Stroke within the past 3 months
- Any FDA contraindications for nicotine replacement therapy use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
M
Maritza Esqueda-Medina
CONTACT
A
Amanda Mathew
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here