Actively Recruiting
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Led by Vanderbilt University Medical Center · Updated on 2026-01-16
20
Participants Needed
1
Research Sites
517 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hypotension. The causes of this are not fully understood. The purpose of this study is to evaluate whether applying local heat over the abdomen of patients with autonomic failure and supine hypertension during the night would decrease their nocturnal high blood pressure while lying down. This will help us better understand the mechanisms underlying this phenomenon, and may be of use in the treatment of supine hypertension.
CONDITIONS
Official Title
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients between 18 and 80 years old with primary autonomic failure (including Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension defined as systolic blood pressure ≥150 mmHg
- Patients able and willing to provide informed consent
You will not qualify if you...
- Pregnancy
- Significant cardiac, kidney, or liver illness
- Contraindications to pressor agents
- Other factors that may prevent completing the study, including clinically significant abnormalities in clinical, mental, or laboratory tests as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Autonomic Dysfunction Center/ Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
B
Bonnie K Black, RN
CONTACT
I
Italo Biaggioni, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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