Actively Recruiting
Oxalate and Citrate in Humans - Response to Citrate
Led by University of Chicago · Updated on 2025-12-16
24
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
Sponsors
U
University of Chicago
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.
CONDITIONS
Official Title
Oxalate and Citrate in Humans - Response to Citrate
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 70 years
- History of at least one calcium-based kidney stone (for stone formers)
- No history of kidney stones (for non-stone formers)
- 24-hour urine oxalate within normal laboratory range (<50 mg/day) for non-stone formers
You will not qualify if you...
- History of primarily uric acid, cystine, or struvite kidney stones
- History of severe acid-base abnormalities
- Urine citrate less than 100 mg/day or greater than 1500 mg/day
- Use of diuretic medications or alkali supplements that cannot be safely stopped during the study
- Chronic kidney disease with glomerular filtration rate less than 75 mL/min/1.73 m²
- Extreme urine citrate levels in either stone formers or non-stone formers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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