Actively Recruiting
Oxalate Formation From Ascorbic Acid
Led by University of Alabama at Birmingham · Updated on 2026-03-09
136
Participants Needed
1
Research Sites
263 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both normal BMI and obese adult non-stone formers and calcium oxalate stone formers. The studies proposed will use diets of known nutrient composition, a stable isotope of ascorbic acid (13C6-AA) and mass spectrometric techniques to quantify ascorbic acid turnover to oxalate.
CONDITIONS
Official Title
Oxalate Formation From Ascorbic Acid
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent
- For stone formers: most recent stone is over 50% calcium oxalate with no uric acid
- For stone formers: first or recurrent calcium oxalate stone with event in prior 3 years
- Two 24-hour urine collections with creatinine excretion within 20% of expected for gender and weight
- Willing to stop supplements (vitamins, calcium, minerals, herbal, probiotics) for 2 weeks before and during study
- Willing to avoid vigorous exercise during study
- Normal fasting Comprehensive Metabolic Panel (CMP)
- Willing to eat menus prepared at Clinical Research Unit
- No allergies or intolerances to study foods
- Stable dose of stone prevention medications for at least 8 weeks prior and during screening if applicable; stop allopurinol 2 weeks before screening and during study
You will not qualify if you...
- Diabetes
- Gout
- Hypertension
- Estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73m2
- Primary hyperoxaluria
- Nephrotic syndrome
- Enteric hyperoxaluria
- Renal tubular acidosis
- Primary hyperparathyroidism
- Liver disease
- Autoimmune disorders
- Neurogenic bladder
- Urinary diversion
- Bariatric surgery
- Active cancer or cancer treatment within 12 months
- Pregnancy
- Breastfeeding or nursing
- Females of childbearing age unable to use effective birth control
- Mental or medical conditions that may prevent study completion
- Illness such as flu, cold, or fever within 14 days before or during study
- Diarrhea or abnormal bowel events within 14 days before or during study
- Abnormal fasting Comprehensive Metabolic Panel (CMP)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35243-3353
Actively Recruiting
Research Team
D
Demond Wiley
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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