Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis.
Abdul-Rehman Phull, Bakht Nasir, Ihsan Ul Haq...
https://pubmed.ncbi.nlm.nih.gov/29258867Actively Recruiting
Age: 18Years +
All Genders
ID07536529
Investigation of the Role of Redox Status in Patients With Autoimmune Rheumatic Diseases on Disease Progression: An Epidemiological Study
Led by University of Thessaly · Updated on 2026-04-28
200
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
Sponsors
U
University of Thessaly
Lead Sponsor
G
George Metsios, Professor, Department of Nutrition and Dietetics, University of Thessaly, Greece
Collaborating Sponsor
AI-Summary
What this Trial Is About
Autoimmune rheumatic diseases (ARDs) are chronic inflammatory conditions that include rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, myositis, Sjogren's syndrome, and systemic scleroderma. These diseases cause joint damage and affect the body systemically, often alongside other health issues like cardiovascular disease and obesity. Researchers are studying the role of oxidative stress, a condition caused by an imbalance of free radicals and antioxidants in the blood, to better understand disease progression and improve monitoring methods for ARDs. This observational study will assess specific redox biomarkers in the blood of patients with ARDs at three time points: Day 1, Day 180, and Day 360. These biomarkers include reduced glutathione, catalase enzyme activity, total antioxidant capacity, and protein carbonyl concentration. In addition, inflammation markers like C-reactive protein and erythrocyte sedimentation rate will be measured. The study also collects data on physical activity, health status, quality of life, fatigue, sleep quality, nutritional habits, and medication history to explore their relationship with disease progression. Participants will provide blood samples and complete questionnaires at the three scheduled visits over one year. The study will evaluate changes in biomarker levels and clinical measures of disease severity, such as DAS28, PASI, and SLEDAI scores. This comprehensive assessment aims to determine whether redox biomarkers can serve as useful tools for tracking ARD progression. The study is sponsored by the University of Thessaly and plans to conclude by October 2026.
CONDITIONS
Brief Title
Oxidative Stress in Autoimmune Rheumatic Diseases
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients over 18 years old with a primary diagnosis of rheumatoid arthritis using ACR criteria
- Adult patients over 18 years old with a primary diagnosis of psoriatic arthritis using CASPAR criteria
- Adult patients over 18 years old with a primary diagnosis of ankylosing spondyloarthritis using ASAS criteria
- Adult patients over 18 years old of any gender
- Adult patients over 18 years old of any ethnicity
- Adult patients over 18 years old with any comorbidities
- Adult patients over 18 years old with any socioeconomic background
- Adult patients over 18 years old with any disease status
- Adult patients over 18 years old with any disease duration
- Adult patients over 18 years old under any treatment scheme including non-steroidal anti-inflammatory drugs, steroids, and disease-modifying anti-rheumatic drugs including biologics
You will not qualify if you...
- Adult patients over 18 years old with a concurrent infectious disease
- Adult patients over 18 years old who are pregnant
- Patients under 18 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Approximately 12 months
Participants have their blood redox status and various health parameters measured at multiple time points to observe disease progression.
3 visits (in-person) on Days 1, 180, and 360
Trial Site Locations
Total: 1 location
1
General University Hospital of Larissa. Greece
Larissa, Thessaly, Greece
Actively Recruiting
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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Published Research Related To This Trial
Impact of Nutrition and Physical Activity Interventions Provided by Nutrition and Exercise Practitioners for the Adult General Population: A Systematic Review and Meta-Analysis.
Erin Nitschke, Kimberly Gottesman, Peggy Hamlett...
https://pubmed.ncbi.nlm.nih.gov/35565696