Actively Recruiting
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
Led by Uppsala University Hospital · Updated on 2025-05-11
65
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. The study focuses on patients over 18 years old who are having planned heart surgery with a heart-lung machine (cardiopulmonary bypass). The main questions the study aims to answer are: 1. How does oxygen consumption in the early hours after surgery relate to lactate levels (a sign of low oxygen supply to the tissues)? 2. How is oxygen consumption linked to signs of poor blood flow and organ injury (such as heart, kidney, liver, brain, and gut damage)? Researchers will measure oxygen consumption after surgery using a technique called indirect calorimetry. They will also track blood flow and oxygen use during surgery and check for signs of organ injury the day after the procedure. The study will include 65 participants. People with certain health conditions, like severe anemia, high lactate levels before surgery, or needing intensive care or extra oxygen supply before surgery, will not be included. By understanding how oxygen consumption relates to blood flow and organ injury, this research may help to better manage patients after heart surgery and reduce complications.
CONDITIONS
Official Title
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elective cardiac surgery requiring cardiopulmonary bypass
You will not qualify if you...
- Combined, redo or annuloplasty procedures
- Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation
- Preoperative hyperlactatemia (>2mmol/L) or anaemia (Hb <90 g/dL)
- Preoperative need for supplementary oxygen or ICU care
- Consent not obtainable
AI-Screening
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Trial Site Locations
Total: 1 location
1
Uppsala University Hospital
Uppsala, Sweden, Sweden
Actively Recruiting
Research Team
J
Julia Jakobsson MD PhD
CONTACT
O
Olle Lönnemark MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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