Actively Recruiting
Oxygen Consumption, Early Postoperative Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass: a Prospective Observational Study
Led by Uppsala University Hospital · Updated on 2025-05-11
65
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. It focuses on patients over 18 years old undergoing planned heart surgery with the use of a heart-lung machine, known as cardiopulmonary bypass. The study seeks to explore how early postoperative oxygen consumption connects with lactate levels and signs of tissue damage in organs like the heart, kidneys, liver, brain, and gut. Participants will have their oxygen consumption measured after surgery using indirect calorimetry, a technique involving a metabolic monitor connected to the ventilator for at least 20 minutes in the intensive care unit. Researchers will also observe blood flow and oxygen use during surgery and assess organ injury markers before surgery and the day after. The study plans to include 65 participants, all undergoing elective cardiac surgery with cardiopulmonary bypass. During the study, participants will be monitored for oxygen consumption in the first hours after surgery, as well as related blood flow and organ injury indicators. Researchers will collect data on oxygen delivery and consumption during and after surgery, and evaluate biomarkers for organ injury. This observational study will help clarify the connection between oxygen use and tissue damage, potentially improving patient management after heart surgery. The study is expected to run until February 2026.
CONDITIONS
Brief Title
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elective cardiac surgery requiring cardiopulmonary bypass
You will not qualify if you...
- Combined, redo or annuloplasty procedures
- Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation
- Preoperative hyperlactatemia (>2mmol/L) or anaemia (Hb <90 g/dL)
- Preoperative need for supplementary oxygen or ICU care
- Consent not obtainable
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 4 hours after surgery
Participants undergo oxygen consumption measurement using indirect calorimetry after arrival to the ICU, prior to cessation of intravenous anaesthetics and extubation.
1 visit (in-person)
Duration - Up to 1 day after surgery
Participants are observed for hypoperfusion parameters, oxygen delivery and consumption during and after surgery, and organ injury biomarkers before and the day after surgery.
1 to 2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Uppsala University Hospital
Uppsala, Sweden, Sweden
Actively Recruiting
Research Team
J
Julia Jakobsson MD PhD
O
Olle Lönnemark MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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