Study on Oxygen Use, Blood Flow Problems, and Organ Injury After Planned Heart Surgery with Heart-Lung Machine

What this Trial Is About

This research aims to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. It focuses on patients over 18 years old undergoing planned heart surgery with the use of a heart-lung machine, known as cardiopulmonary bypass. The study seeks to explore how early postoperative oxygen consumption connects with lactate levels and signs of tissue damage in organs like the heart, kidneys, liver, brain, and gut. Participants will have their oxygen consumption measured after surgery using indirect calorimetry, a technique involving a metabolic monitor connected to the ventilator for at least 20 minutes in the intensive care unit. Researchers will also observe blood flow and oxygen use during surgery and assess organ injury markers before surgery and the day after. The study plans to include 65 participants, all undergoing elective cardiac surgery with cardiopulmonary bypass. During the study, participants will be monitored for oxygen consumption in the first hours after surgery, as well as related blood flow and organ injury indicators. Researchers will collect data on oxygen delivery and consumption during and after surgery, and evaluate biomarkers for organ injury. This observational study will help clarify the connection between oxygen use and tissue damage, potentially improving patient management after heart surgery. The study is expected to run until February 2026.

Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass