Actively Recruiting
Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)
Led by Leiden University Medical Center · Updated on 2024-09-19
60
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In patients who are mechanically ventilated for more than 72 hours weaning failure is a common issue. The Spontaneous breathing trial (SBT) is often done to assess if the patient can be extubated with a high chance of success. However, re-intubation rates are between 15 - 20 % after a successful SBT. The rapid shallow breathing index (RSBI) is an important parameter used in an SBT. Because the high incidence of extubation failure (re-intubation within 48 hours) a search for a better parameter than the RSBI is warranted. Using the measured end-tidal oxygen (etO2) of mechanically ventilated patients it is possible to calculate the VO2, which is a measure of patient effort. The VO2 is a parameter with the potential to predict weaning success or failure, together with other parameters of patient effort like the work of breathing (WOB), pressure time product (PTP) and esophageal pressure swings, reflecting muscle strength of the diaphragm. Therefore, the investigators want to investigate if these parameters are associated with an SBT success or failure.
CONDITIONS
Official Title
Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age above 18 years
- More than 24 hours mechanically ventilated
- Eligible for a spontaneous breathing trial as decided by the clinical team
- Undergoing regular spontaneous breathing trial according to Leiden University Medical Center protocol
- Hemodynamically stable
- Esophageal catheter in place
You will not qualify if you...
- Severe chronic obstructive pulmonary disease (COPD) classified as Gold class IV that results in a non-regular spontaneous breathing trial
- Heart failure with left ventricular ejection fraction less than 30% that results in a non-regular spontaneous breathing trial
- Known pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Leiden University Medical Centre
Leiden, South Holland, Netherlands, 2333 ZA
Actively Recruiting
2
Leiden University Medical Center
Leiden, Netherlands, 2333ZA
Not Yet Recruiting
Research Team
F
Florence E Smits, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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