Actively Recruiting
Oxygen Extraction-guided Transfusion
Led by Università degli Studi di Ferrara · Updated on 2026-05-01
324
Participants Needed
4
Research Sites
164 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level \< 7.0 g/dL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients \[11\]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.
CONDITIONS
Official Title
Oxygen Extraction-guided Transfusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hemoglobin levels 9.0 g/dL or lower confirmed by blood test or blood gas analysis
- Presence of an arterial line and a central venous line with correct catheter tip position at the atrio-caval junction for measuring central venous saturation
You will not qualify if you...
- Younger than 18 years old
- Pregnancy
- Clinical evidence of acute bleeding
- Diagnosis of hematological malignancy
- Diagnosis of sickle cell disease or other diseases requiring chronic red blood cell transfusions
- Acquired or congenital blood clotting disorders
- Ongoing acute kidney injury stage 1 or worse, or chronic kidney disease stage G3a or worse (glomerular filtration rate below 60 for at least 3 months)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Hospital Erasme
Brussels, Belgium
Not Yet Recruiting
2
Università di Ferrara
Ferrara, Ferrara, Italy, 44121
Actively Recruiting
3
Università di Perugia
Perugia, Italy, Italy, 06121
Actively Recruiting
4
Anestesia e Rianimazione Cardio-Toraco-Vascolare
Siena, Italy
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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