Actively Recruiting
Oxygenation Procedure for Obese Patients During Intubation in the Operating Room
Led by Clinique Pasteur · Updated on 2026-03-06
124
Participants Needed
5
Research Sites
88 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.
CONDITIONS
Official Title
Oxygenation Procedure for Obese Patients During Intubation in the Operating Room
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient requiring general anaesthesia with orotracheal intubation in the operating room
- Obese patient (Body Mass Index , BMI 65 30kg/m2)
- Patient affiliated to or benefiting from a social security scheme
- Patient having signed the free and informed consent form.
You will not qualify if you...
- Haemodynamic instability
- Intubation without laryngoscopy (fibroscope intubation) or nasotracheal intubation
- Emergency surgery not allowing patient consent
- Patient with a contraindication to NIV or OHD
- Protected patients: Adults under guardianship, curatorship or other legal protection; deprived of liberty by judicial or administrative decision; pregnant, breast-feeding or parturient women; hospitalised without consent.
AI-Screening
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Trial Site Locations
Total: 5 locations
1
CHU Clermont Ferrand - Site Estaing
Clermont-Ferrand, France, 63100
Actively Recruiting
2
Clinique Honoré Cave
Montauban, France, 82000
Actively Recruiting
3
Hôpital Saint Eloi - CHU Montpellier
Montpellier, France, 34295
Actively Recruiting
4
Clinique Mutualiste La Sagesse
Rennes, France, 35000
Actively Recruiting
5
Clinique Pasteur
Toulouse, France, 31000
Actively Recruiting
Research Team
S
Ségolène MROZEK, MD, PhD
CONTACT
S
Stéphanie SAVY, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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