Oxygenation in Vascular Lesions of the Colon Comparing People With Acquired Vascular Abnormalities and Healthy Controls

What this Trial Is About

Researchers are studying oxygen levels in the colon of people who have acquired vascular abnormalities in the proximal colon, such as angiodysplasia, arteriovenous malformations, and hemangiomas. These lesions are often found in older adults and those with heart, lung, or kidney conditions, and they may cause bleeding or iron deficiency anemia. The study aims to understand whether chronic low oxygen levels contribute to these vascular lesions by comparing affected individuals to healthy controls. Participants are divided into two groups: those with vascular abnormalities in the proximal colon and those with healthy colons. Researchers will measure oxygen saturation in five locations within the proximal colon mucosa during standard colonoscopy procedures. This study is non-randomized and does not involve blinding. The main evaluation will track colonic oxygen saturation levels from baseline up to 12 months. During the study, participants will undergo colonoscopies as part of their standard care, where oxygen levels in the colon will be quantitatively measured. The team will monitor oxygen saturation to understand the role of oxygenation in these lesions. Participants may be followed for up to one year to assess changes over time. The trial is open to adults aged 18 to 89 years, including both those with vascular lesions and healthy volunteers.

Oxygenation in Vascular Lesions of the Colon