Actively Recruiting
Oxytocin Plus Self-compassion Training in Borderline Personality Disorder
Led by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Updated on 2026-04-27
80
Participants Needed
1
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Borderline personality disorder (BPD) is a frequentand serious psychiatric disorder characterized by a persistent pattern of instability in relationships, affect and self-image. Although long-term follow-up prospective studies have shown high clinical remission rates, they also point out that usually persist social functioning deficits, comorbidity, isolation, chronic affective clinic and life dissatisfaction. Self-compassion training (SCT) could be an effective strategy targeting self-criticism, shame and chronic feelings of worthlessness, as well as increasing resilience. In addition, the administration of intranasal oxytocin has proven useful in regulating social cognition, affiliation behaviors and enhancing empathy, key symptoms in this population. This combined intervention could be particularly appropriate for BPD patients. Objective: The objective of this project is to implement and evaluate the effectiveness of a combined intervention, based on SCT and intranasal oxytocin administration, for the treatment of patients with BPD. Methodology: Controlled and randomized clinical trial. A self-compassion training of 5 weeks duration plus intranasal oxytocin administration versus SCT plus placebo will be compared in a sample of 80 patients with BPD. Clinical and wellness measures will be evalutated as outcomes.
CONDITIONS
Official Title
Oxytocin Plus Self-compassion Training in Borderline Personality Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Borderline Personality Disorder (BPD) confirmed by SCID-II and DIB-R interviews
- Age between 18 and 50 years, inclusive
- Stable pharmacological treatment throughout the intervention
- Previous treatment with Standard Dialectical Behavior Therapy (DBT) or DBT Skills Training
- High self-criticism with scores above 12 on the Inadequate Self subscale of FSCRS-SF
You will not qualify if you...
- Presence of comorbid psychiatric disorders such as Schizophrenia, Psychotic Disorders, Bipolar Disorder, Current Major Depressive Disorder, Substance Dependence, Organic Brain Disease, or Intellectual Disability
- History of severe endocrine disorders
- History of Epilepsy, Renal Insufficiency, or Heart Failure
- Concurrent participation in other psychotherapy or psychological treatments
- Women of childbearing potential unwilling or unable to use effective contraception throughout the study
- Intention to become pregnant or planning pregnancy during the study
- Current pregnancy or breastfeeding at enrollment or during the study
- Use of medical treatments incompatible with intranasal oxytocin administration
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain, 08041
Actively Recruiting
Research Team
P
Principal Investigator JCP JCP, PhD
CONTACT
C
Co-IP (JS) JS J Soler
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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