Actively Recruiting
Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus
Led by University Hospital, Basel, Switzerland · Updated on 2026-05-06
112
Participants Needed
3
Research Sites
142 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) to improve psychological symptoms and socio-emotional functioning. Optionally, patients can present for additional assessments in sub-studies: * fMRI sub-study at day 14 (± 2 days) (one additional visit) * Social-stress sub-study at day 14 (± 2 days) (one additional visit)
CONDITIONS
Official Title
Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with a confirmed diagnosis of central diabetes insipidus based on accepted criteria
- Heightened anxiety levels (STAI - Trait subscale 29e 39 score points) or alexithymia levels (TAS-20 total 29e 52 score points)
- Stable hormone replacement therapy for at least three months with desmopressin and, if needed, other hormone substitutions
You will not qualify if you...
- Participation in a trial with investigational drugs within 30 days
- Active substance use disorder within the last six months
- Consumption of alcoholic beverages more than 15 drinks per week
- Current or previous psychotic disorder such as schizophrenia
- Pregnancy or breastfeeding within the last eight weeks
- Unwillingness to use medically acceptable contraception during the study (for women able to become pregnant)
- Prolonged QTc-time greater than 470 ms on electrocardiogram
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Charité University Medical Center Berlin
Berlin, Germany, 10117
Actively Recruiting
2
Erasmus University Medical Center Rotterdam
Rotterdam, Netherlands, 3015
Actively Recruiting
3
University Hospital Basel, Department of Endocrinology, Diabetes & Metabolism
Basel, Switzerland, 4031
Actively Recruiting
Research Team
M
Mirjam Christ-Crain, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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