Actively Recruiting
Pacing of Left Bundle Branch Area and Atroventricular Node ablatIon in Patients With Symptomatic Atrial Fibrillation
Led by Seoul National University Hospital · Updated on 2025-05-18
50
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aimed to compare the clinical outcomes of left bundle branch area pacing combined with atrioventricular node ablation and pharmacologic treatment optimized according to guidelines in patients with symptomatic atrial fibrillation refractory or intolerant to drug therapy or catheter ablation.
CONDITIONS
Official Title
Pacing of Left Bundle Branch Area and Atroventricular Node ablatIon in Patients With Symptomatic Atrial Fibrillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Permanent atrial fibrillation
- Age 65 years or older
- Refractory or intolerant to antiarrhythmic drugs, rate control medications, or catheter ablation
- New York Heart Association (NYHA) functional class II to IV
- Left ventricular ejection fraction (LVEF) greater than 40% within the past 3 months
- At least one of the following: hospitalization for heart failure within 12 months, or elevated NT-proBNP greater than 900 pg/ml within 30 days prior to enrollment
You will not qualify if you...
- Asymptomatic atrial fibrillation
- Life expectancy less than 12 months
- Primary moderate to severe valvular disease (except functional mitral or tricuspid valve regurgitation)
- Mechanical tricuspid valve replacement
- Severe chronic kidney disease (eGFR 15 ml/1.73 m2 or less) or receiving renal replacement treatment
- Obstructive hypertrophic cardiomyopathy
- Infiltrative cardiomyopathy (amyloidosis, sarcoidosis, Fabry disease, others)
- Acute coronary syndrome or coronary revascularization within 3 months
- Severe primary pulmonary disease requiring inhalers or oxygen supplementation
- Ongoing pacemaker, ICD, or CRT treatment, or current pacemaker indication
- Participation in another randomized clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Seoul National University Hospital
Seoul, Jongno-gu, South Korea, 03080
Actively Recruiting
Research Team
E
Eue-keun Choi, M.D. Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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