Actively Recruiting
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
Led by Region Skane · Updated on 2026-05-14
300
Participants Needed
3
Research Sites
263 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest. PAINCARE aims to describe the burden of pain during early intensive care after cardiac arrest and to evaluate associations between early pain burden and selected ICU and patient-reported outcomes. Pain is common in critically ill patients but may be difficult to assess in patients who are unconscious, sedated, mechanically ventilated, or unable to self-report. PAINCARE collects structured pain assessments during the first 168 hours after randomization using validated self-report or behavioral pain instruments and relates early pain burden to outcomes including delirium burden, ventilator-free time, ICU-free time, and follow-up pain outcomes. All analyses are observational; PAINCARE is not designed to determine whether modifying pain burden improves outcomes.
CONDITIONS
Official Title
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Out-of-hospital cardiac arrest
- Adult, age 18 years or older
- Spontaneous circulation without chest compressions for at least 20 minutes
- Comatose, defined as not obeying verbal commands
- Enrolled within 4 hours after return of spontaneous circulation
You will not qualify if you...
- Restrictions or limitations of care
- On extracorporeal membrane oxygenation before randomization
- Pregnancy
- Previously randomized in the STEPCARE trial
- Trauma or hemorrhage as the presumed cause of arrest
- Suspected or confirmed intracranial hemorrhage
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Dep. of Intensive Care Halmstad Lasarett
Halmstad, Sweden
Actively Recruiting
2
Department of Intensive Care, Skåne University Hospital
Malmö, Sweden, 20205
Actively Recruiting
3
Dep. of Intensive Care, Norrlands Universitets Sjukhus
Umeå, Sweden
Actively Recruiting
Research Team
J
Joachim P Düring, MD, PhD
CONTACT
M
Mia H Hylén, RN, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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