Actively Recruiting
Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder
Led by University Hospital, Toulouse · Updated on 2026-05-01
24
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, with over 12 million patients expected globally by 2040. The disease is currently diagnosed at the appearance of motor symptoms, but by then, over 60% of striatal dopaminergic neurons have already been destroyed. Prodromal symptoms such as idiopathic REM Sleep Behavior Disorder (iRBD), anosmia, mood disorders and constipation appear earlier and are listed as criteria for a prodromal PD diagnosis. Identifying early signs is critical to initiate neuroprotective treatments as early as possible. While pain is prevalent and highly disabling in early PD, no data are currently available on pain perception in iRBD patients, whose condition is of the main risk factor for PD development.
CONDITIONS
Official Title
Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with idiopathic REM Sleep Behavior Disorder confirmed by polysomnography
- No clinical diagnosis of Parkinson's disease or other neurodegenerative diseases
- Ability to understand and complete study procedures and questionnaires
- For control group: diagnosed with narcolepsy type 1
- Control group with coexisting REM sleep behavior disorder confirmed by polysomnography
- Control group able to understand and complete study procedures and questionnaires
You will not qualify if you...
- Diagnosed Parkinson's Disease, dementia with Lewy bodies or multiple system atrophy
- Severe depression according to DSM V
- Inability to complete study procedures or questionnaires
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Expert Parkinson Hôpital Pierre Paul Riquet Place du Docteur Baylac
Toulouse, France, 31059
Actively Recruiting
Research Team
C
Christine BREFEL COURBON
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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