Actively Recruiting
Pain and Disability Outcomes in Post Amputation Patients
Led by Milton S. Hershey Medical Center · Updated on 2026-05-07
350
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of various medical and procedural treatments used to manage pain after surgical limb amputation. The study focuses on understanding how different therapies, such as peripheral nerve blocks, epidurals, and peripheral nerve stimulators, impact phantom pain and somatic pain over the long term. The goal is to determine whether the timing of these interventions, before or after amputation, influences the development of chronic pain and phantom limb pain. Participants who have undergone limb amputation will be observed to assess pain severity at rest and with movement using a Numerical Rating Scale (NRS) from 0 to 10, where 0 means no pain and 10 is the worst pain imaginable. Pain assessments will be collected on postoperative days 1 and 7, then at 30 days, 90 days, 6 months, and one year, with a small window of +/- 3 days for each. The study also measures other outcomes like phantom limb pain severity, residual limb pain, phantom limb sensations, pain disability scores, and the amount of pain medication used. During the study, participants will have regular pain evaluations at specified intervals up to one year. This includes questionnaires and pain scoring to track changes over time. Researchers will also gather data on phantom sensations and disability related to pain. The study aims to better understand which treatment methods and timing may reduce pain and improve quality of life after amputation. Participation involves scheduled assessments and follow-up visits over one year to monitor outcomes and medication use.
CONDITIONS
Brief Title
Pain and Disability Outcomes in Post Amputation Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages between 18 and 89 years old, inclusive
- Patients scheduled for surgical limb amputation at Penn State Hershey Medical Center
You will not qualify if you...
- Patients who cannot cooperate or consent
- Patients who cannot understand or speak English
- Patients with a history of chronic regional pain syndromes
- Patients suffering from alcohol and/or drug abuse based on previous diagnosis
- Body mass index (BMI) greater than 50
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 week
Participants undergo surgical limb amputation and immediate post-operative care where various medical and procedural pain therapies may be administered.
1 visit on postoperative day 1 and 1 visit on day 7
Duration - Up to 1 year
Participants are followed up to assess pain severity, phantom limb pain, sensations, disability, and medication use over time.
Visits on postoperative days 30, 90, 6 months, and 1 year
Trial Site Locations
Total: 1 location
1
Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
Research Team
S
Sanjib Adhikary, M.B.B.S, MD
C
Cynthia Reed, BS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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