Actively Recruiting
Pain and Major Depressive Disorder
Led by University of California, Los Angeles · Updated on 2025-09-19
54
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 treatments of blinded transcranial magnetic stimulation. There is no control group as all subjects will receive some form of active treatment. Subjects are required to participate in 30-33 study visits and volunteer 40 hours of their time. Compensation for this study is $150 for completing all study activities.
CONDITIONS
Official Title
Pain and Major Depressive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Fluent in English with ability to understand and answer study questions
- Right-handed
- Confirmed diagnosis of moderate Major Depressive Disorder with a minimum score of 17 on the Hamilton Rating Scale for Depression
- Failure to respond to at least two antidepressant medication trials from different drug classes
- Use of at least two evidence-based augmentation therapies (excluding benzodiazepines)
- Completed a trial of psychotherapy effective for MDD with adequate frequency and duration
- Diagnosed with fibromyalgia or myalgic encephalomyelitis/chronic fatigue syndrome with moderate pain
- Chronic pain lasting at least 3 months before enrollment
- Willing and able to follow the treatment schedule and attend required visits
You will not qualify if you...
- Mentally or legally incapacitated and unable to give informed consent
- Pregnant
- Active suicidal intent or plan
- Prior Transcranial Magnetic Stimulation treatment
- Infection or poor skin condition on scalp where device is applied
- Increased seizure risk due to family history, stroke, or medications
- Psychotic depression or other current psychotic disorders
- Neurological conditions such as epilepsy, stroke, dementia, increased intracranial pressure, severe head trauma, or CNS tumors
- Presence of implanted metallic or magnetic-sensitive medical devices (excluding dental fillings)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA Semel Institute
Los Angeles, California, United States, 90024
Actively Recruiting
Research Team
D
Doan Ngo, BS
CONTACT
J
Juliana Corlier, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here