Actively Recruiting
Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
Led by University of Zurich · Updated on 2026-05-12
300
Participants Needed
1
Research Sites
314 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain after SCI. The functionality of the nociceptive pathway in humans as well as its plastic changes following SCI will be inferred with sophisticated sensory and pain phenotyping using quantitative sensory testing (i.e., psychophysical measures), objective neurophysiological measures of pain processing and the recording of pain-related autonomic responses (i.e., galvanic skin response, cardiovascular measures and pupil dilation). In addition, the interplay between the somatosensory and autonomic nervous system and its association with the development and maintenance of neuropathic pain after SCI will be investigated.
CONDITIONS
Official Title
Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 to 80 years
- For spinal injury cohort: traumatic or non-traumatic spinal cord injury, including para- and tetraplegic, complete or incomplete, with or without neuropathic pain
- For longitudinal spinal injury study: spinal cord injury occurred less than one month ago
- For cross-sectional spinal injury study: spinal cord injury occurred more than one year ago
- For peripheral neuropathy cohort: neurological disorder affecting peripheral nervous system with or without neuropathic pain
- For longitudinal peripheral neuropathy study: peripheral neuropathy occurred less than one month ago
- For cross-sectional peripheral neuropathy study: peripheral neuropathy occurred more than one year ago
- For control cohort without neuropathy: no medical condition affecting peripheral or central nervous system (e.g., no pain, systemic or psychological disorder)
You will not qualify if you...
- Inability to follow study instructions
- Pregnancy
- Medically manifested psychological disorder
- Medical condition affecting peripheral or central nervous system other than the study condition (e.g., additional peripheral neuropathy in spinal cord injury cohort)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland, 8008
Actively Recruiting
Research Team
M
Michèle Hubli, PD Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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