Actively Recruiting
Pain Reprocessing Therapy in Post-Operative Knee Pain
Led by University of Colorado, Denver · Updated on 2026-03-31
110
Participants Needed
2
Research Sites
163 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
H
Hospital for Special Surgery, New York
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.
CONDITIONS
Official Title
Pain Reprocessing Therapy in Post-Operative Knee Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients eligible at 3 months after primary knee replacement surgery with no complications and full joint function
- Average knee pain score of 4 or higher out of 20 during the last week
- At least two moderate ratings on a knee pain questionnaire (ShortMAC of WOMAC)
- Chronic knee pain lasting at least 6 months before surgery
- Surgery was a primary knee replacement (not a revision)
- Ability to understand and speak English
You will not qualify if you...
- Unwillingness to participate in telehealth visits
- No post-operative knee pain at 3 months after surgery
- Active suicidal thoughts with intent or recent suicide attempts or self-harm behavior in past 5 years
- Recent inpatient psychiatric hospitalization in past 5 years
- Current psychosis or mania
- Current or recent (past 2 years) substance abuse
- Unstable living conditions or major life events interfering with participation or telehealth access
- Neurological disorders that might interfere with treatment
- Diagnosis of autoimmune diseases such as rheumatoid arthritis, lupus, or scleroderma
- Current or planned legal actions or disability claims related to pain within next 6 months
- History of abnormal EEGs or inability to tolerate dry cap EEG (for EEG testing exclusion)
- History of bilateral total knee arthroplasty (for EEG testing exclusion)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Active, Not Recruiting
2
Hospital for Special Surgery
New York, New York, United States, 10021
Actively Recruiting
Research Team
A
Allina Nocon, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here