Evaluating Pain Reprocessing Therapy Compared to Usual Care for Adults with Chronic Knee Pain After Knee Replacement

What this Trial Is About

This research aims to evaluate the effects of Pain Reprocessing Therapy PRT, a new psychological treatment, for adults experiencing chronic knee pain after knee replacement surgery. The study compares PRT to usual care to determine which approach is better for reducing pain and improving related factors like anxiety, depression, and sleep. It also investigates how PRT impacts brain activity related to pain. Participants will be randomly assigned to receive either PRT or continue with usual care. PRT involves eight weekly 50-minute therapy sessions delivered remotely via video calls by trained clinicians. Usual care participants continue their current pain management routine for about eight weeks. An optional EEG test to measure brain activity related to pain is also offered. During the study, participants will complete questionnaires about their pain and overall health at multiple time points. The main outcome measured is pain intensity at approximately 12, 18, and 26 weeks after starting the treatment. Other outcomes include pain interference, depression, anxiety, fatigue, and opioid use. Participants progress and safety will be monitored throughout the trial.

Pain Reprocessing Therapy in Post-Operative Knee Pain