Actively Recruiting
Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
Led by Vanderbilt University Medical Center · Updated on 2026-01-21
220
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
V
Vanderbilt University Medical Center
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work. Emotional suffering is common in IC/BPS and known to make physical symptoms worse, and studies show patient sub-groups respond differently to treatment. Individuals with IC/BPS have distinct subgroups, or "phenotypes," largely characterized by the distribution of pain throughout the body. Supported by our preliminary evidence, the overall goal of this project is to assess how IC/BPS phenotype may affect response to two different therapies often given without regard to patient phenotype, pelvic floor physical therapy (PT) and cognitive-behavioral therapy (CBT) for IC/BPS.
CONDITIONS
Official Title
Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Diagnosis of IC/BPS as indicated by structured assessments
- Capable of giving written informed consent
- Able to enroll for the duration of the study period
You will not qualify if you...
- Comorbid neurological conditions including spinal cord injury or systematic neurologic illnesses, or central nervous system diseases such as brain tumor or stroke
- Current or history of diagnosis of primary psychotic or major thought disorder within the past five years
- Hospitalization for psychiatric reasons other than suicidal ideation, homicidal ideation, and/or PTSD within the past 5 years
- Psychiatric or behavioral conditions with unstable or severe symptoms in past six months (e.g., delirium, mania, psychosis, active suicidal ideation, homicidal ideation, substance abuse dependency)
- Non-English speaking
- Presenting symptoms interfering with participation such as active suicidal ideation with intent or active delusional or psychotic thinking
- Difficulties or limitations communicating over telephone or teleconferencing
- Any planned life events interfering with study participation
- Any major active medical issues that could preclude participation
- Currently pregnant
- Currently being treated for cancer
- Cancer-related pain
- Recently or actively participating in treatment similar to those being investigated (e.g., individual psychotherapy or pelvic floor physical therapy)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt Urology Cool Springs
Franklin, Tennessee, United States, 37067
Actively Recruiting
Research Team
L
Lindsey McKernan, PhD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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