Comparing Stroke Volume Variation and Pleth Variability Index to Predict Fluid Responsiveness During Elective Laparoscopic Major Abdominal Surgery in Adults

What this Trial Is About

Researchers are comparing two operating-room monitors Stroke Volume Variation SVV from an arterial line and Pleth Variability Index PVI from a pulse oximeter. The goal is to determine which monitor better predicts whether a small fluid bolus improves heart pumping during elective laparoscopic major abdominal surgery under general anesthesia. This study is prospective and observational, focusing on adult patients in a single academic hospital in the Republic of Korea. Participants receive up to two standardized 250-mL crystalloid fluid infusions as part of routine care, one before and one after the creation of the pneumoperitoneum. SVV and PVI values are recorded just before and about three minutes after each infusion by trained staff, while clinicians remain unaware of these readings to avoid changes in usual care. No experimental drugs or devices are used, and fluid challenges are withheld or stopped if safety concerns arise. During the study, participants undergo monitoring of vital signs and waveform measurements. Researchers collect data on SVV and PVI accuracy for predicting fluid responsiveness, defined as a 10% or greater increase in stroke volume index after infusion. Secondary measures include sensitivity, specificity, and hemodynamic changes such as blood pressure and heart rate. The study plans to enroll about 300 adults, with all data securely recorded and handled confidentially.

Paired Comparison of SVV and PVI Accuracy