Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial.
Arul Jothi Murugan, Anuradha Ganesan, Yesoda K Aniyan...
https://pubmed.ncbi.nlm.nih.gov/37726676Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID07409571
Impact of Topical Triamcinolone Acetonide on Palatal Wound Healing, Patient Morbidity, and Quality of Life After Free Gingival Graft Surgery: A Randomized Clinical Trial
Led by Kahramanmaras Sutcu Imam University · Updated on 2026-05-22
55
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of applying topical triamcinolone acetonide on wound healing and patient-reported outcomes at the palatal donor site after free gingival graft (FGG) surgery. This randomized controlled trial includes 55 patients with mucogingival deficiencies requiring FGG. The study aims to compare healing and patient experiences between those receiving a collagen membrane alone and those receiving topical corticosteroid treatment, addressing the common issues of pain, discomfort, and delayed healing at the donor site. Participants will be randomly assigned to one of two groups. The control group will have a collagen membrane applied to the palatal donor site after graft harvesting, while the test group will receive topical triamcinolone acetonide followed by a collagen membrane. Both groups will have the donor site covered with sterile aluminum foil and a periodontal dressing. Surgical procedures will be performed by a single clinician, and evaluations will be done on postoperative days 3, 7, 14, and 30. During the study, wound epithelialization will be assessed using the hydrogen peroxide bubbling test, while wound healing and scar formation will be measured using established clinical indices. Patient-centered outcomes such as pain, discomfort, bleeding, analgesic use, dietary changes, and oral health-related quality of life will be recorded using visual analog scales and questionnaires. This comprehensive monitoring aims to provide evidence on whether topical corticosteroid use can reduce donor site morbidity and improve recovery after FGG surgery.
CONDITIONS
Brief Title
Palatal Wound Healing After Free Gingival Graft Surgery
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older
- Patients with insufficient attached gingiva and/or gingival recession requiring free gingival graft surgery
- Systemically healthy individuals (ASA I)
- Full-mouth plaque score (FMPS) < 15% and full-mouth bleeding score (FMBS) < 15% at the time of surgery
- Ability and willingness to provide written informed consent and comply with study procedures
You will not qualify if you...
- Presence of systemic diseases that may affect wound healing (e.g., diabetes mellitus, immunological disorders)
- Use of systemic corticosteroids, immunosuppressive drugs, or anti-inflammatory medications within the last 3 months
- Current smokers or tobacco users
- Pregnancy or lactation
- History of periodontal surgery at the palatal donor site
- Presence of active infection, ulceration, or pathological lesions at the palatal donor area
- Known allergy or hypersensitivity to corticosteroids, collagen materials, or study-related medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - Day 0
Participants undergo free gingival graft surgery. Following graft harvesting, either a collagen membrane or topical triamcinolone acetonide is applied to the palatal donor site, which is then covered with sterile aluminum foil and a periodontal dressing.
1 surgery visit (in-person)
Post-operative Follow-up
Duration - 30 days
Participants are evaluated for wound healing, pain, discomfort, bleeding, and quality of life following surgery.
Visits on postoperative days 1, 2, 3, 4, 5, 6, 7, 14, and 30 (in-person and/or phone assessments)
Trial Site Locations
Total: 1 location
1
Kahramanmaraş Sütçü İmam University
Kahramanmaraş, Kahramanmaraş, Turkey (Türkiye), 46000
Actively Recruiting
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Research Team
E
esra bozkurt
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial.
M Siponen, L Huuskonen, S Kallio-Pulkkinen...
https://pubmed.ncbi.nlm.nih.gov/28168769