Actively Recruiting

Age: 18Years +
All Genders
NCT02775461

Pancreas Registry and High Risk Registry

Led by Icahn School of Medicine at Mount Sinai · Updated on 2026-02-11

1368

Participants Needed

2

Research Sites

1035 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the pancreas, and patients at high-risk of pancreatic cancer such as those with a family history of pancreatic cancer or with a family history of a syndrome known to be associated with pancreatic cancer. Pancreatic cancer is the fourth leading cause of death from cancer in the United States. However, little is known about the development of pancreatic cancer and pancreatic diseases in individuals with the above conditions. Knowledge of how family history, environmental exposures, and inflammatory lesion of the pancreas contribute to the development of pancreatic cancer and pancreatic diseases is essential. You may qualify to take part in this research study because you have inflammation in the pancreas, a pancreatic cyst, pre-cancerous lesions of the pancreas, pancreatic cancer, a family history of pancreatic cancer, or a family history of a syndrome known to be associated with pancreatic cancer. We will also be collecting a blood sample from all participants for DNA isolation. Sometimes we are born with genes or DNA that give us an increased or decreased chance of developing an illness later in life. Genetic material will be isolated from your blood for further study. You may also choose to provide additional blood samples for serum and plasma extraction. Serum and plasma are components of the blood which can be used to measure indicators of disease in the blood, called biomarkers,for pancreatic diseases. Clinical data and biological specimens contained in this study may be used for a wide variety of future related studies to the cause, diagnosis, outcome and treatment of pancreatic cancer. Funds for conducting this research are provided by Mount Sinai.

CONDITIONS

Official Title

Pancreas Registry and High Risk Registry

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • At least 1 first degree relative affected with Pancreatic Cancer
  • Presence of BRCA1, BRCA2, PALB2, or ATM mutations plus 1 family member with Pancreatic Cancer
  • mFAMMM (p16, CDKN2A mutations) plus 1 family member with Pancreatic cancer
  • Known mutation carrier for STK11 (Peutz Jeghers Syndrome)
  • Lynch syndrome (HNPCC) plus 1 family member with pancreatic ductal adenocarcinoma
  • Known mutation carrier for hereditary pancreatitis
  • Individuals with a history of pancreatic cyst(s) (IPMNs) measuring 1 cm or larger
Not Eligible

You will not qualify if you...

  • Patients who do not speak English or Spanish
  • Refusal by patient to participate
  • Individuals under the age of 18 years

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Mount Sinai West

New York, New York, United States, 10019

Actively Recruiting

2

Icahn School of Medicine at Mount Sinai

New York, New York, United States, 10029

Actively Recruiting

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Research Team

J

Joyce Serebrenik

CONTACT

S

Storey Harbison

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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