Actively Recruiting
Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery
Led by Hamilton Health Sciences Corporation · Updated on 2024-10-10
30
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-arm, single-center feasibility trial of patients with borderline resectable pancreatic adenocarcinoma receiving chemotherapy with mFOLFIRINOX or gemcitabine / nab-paclitaxel followed by pancreatectomy.
CONDITIONS
Official Title
Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 79 years
- Biopsy proven borderline resectable pancreatic adenocarcinoma
- Medically fit for surgery as assessed by treating surgeon
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Normal bone marrow and organ function including ANC ≥ 1500, platelets > 100,000, total bilirubin <1.5 times upper limit of normal, ALT and AST less than 3 times upper limit of normal, creatinine less than 150 umol/L, and normal prothrombin time and INR
- Able to provide written informed consent
You will not qualify if you...
- Presence of metastatic pancreatic cancer
- Locally advanced pancreatic cancer
- Prior radiation therapy to the pancreas or related area
- Contraindications to chemotherapy
- History of significant cardiac disease including congestive heart failure (NYHA class 2), active coronary artery disease, or uncontrolled hypertension
- Current systemic infections
- Illegal substance abuse or social conditions interfering with study participation
- Pre-existing neuropathy
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Juravinski Hospital
Hamilton, Ontario, Canada, L8V1C3
Actively Recruiting
Research Team
L
Leyo Ruo, MD
CONTACT
P
Pablo E Serrano, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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