Actively Recruiting
Pancreatic Cancer Diagnosis With FAPI-PET Imaging
Led by Turku University Hospital · Updated on 2025-08-01
100
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Staging pancreatic cancer (PC) presents a clinical challenge. Triphasic whole body CT is the primary imaging method in diagnosing, staging and during follow up. Conventional PET/CT with 18F-labelled fluorodeoxyglucose (18F-FDG) has its limitations and therefore has a secondary role in imaging pancreatic cancer patients. These conventional imaging methods are good in detecting primary tumors and distant metastasis but poor in detecting local lymph node metastasis. A new PET tracer, fibroblast activation protein inhibitor (FAPI), targets FAP, a protein overexpressed in cancer-associated fibroblasts. It presents a potential new PET imagining tool. The objective of this prospective diagnostic study is to evaluate the diagnostic efficacy of 18F-FAPI-74 PET/CT in patients with PC. The aim is to evaluate the sensitivity and specificity of 18F-FAPI-74 in detection of local lymph node metastasis and distant metastasis in patient level in patients with PC in primary staging and when suspected recurrence. 100 patients with PC are enrolled on whom PET/CT studies are performed with the novel 18F-FAPI-74 tracer. The data will be collected between 2024-2026.
CONDITIONS
Official Title
Pancreatic Cancer Diagnosis With FAPI-PET Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected primary or recurrent pancreatic cancer
- Male or female aged 18 to 85 years
- WHO performance score 0 to 2
- Able and willing to provide written informed consent and comply with study requirements
You will not qualify if you...
- Vulnerable subjects such as disabled, children, pregnant or breastfeeding women, and prisoners
- Unable to understand the purpose of the study
- Medical conditions preventing whole-body PET/CT imaging
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Turku PET Centre, Turku University Hospital
Turku, Finland
Actively Recruiting
Research Team
S
Saila Kauhanen, docent
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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