Actively Recruiting
A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals
Led by Nuvance Health · Updated on 2026-04-13
200
Participants Needed
1
Research Sites
730 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main goal of this study is to screen and detect pancreatic cancer and precursor lesions in individuals with a strong family history or genetic predisposition to pancreatic cancer. Magnetic Resonance Imaging and Magnetic cholangiopancreatography (MRI/MRCP) will be utilized to screen for early stage pancreatic cancer or precursor lesions. Participants will be asked to donate a blood sample at specific intervals for the creation of a bio-bank necessary for the development of a blood based screening test for Pancreatic Cancer.
CONDITIONS
Official Title
A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 50 years old or 10 years younger than the youngest relative with pancreatic cancer
- For familial pancreatic cancer (FPC): at least 2 first-degree relatives with pancreatic cancer
- For FPC: at least 3 first-, second-, or third-degree relatives with pancreatic cancer, including at least 1 first-degree relative
- Known carrier of BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, ATM, PALB2, CDKN2A, or similar high-risk gene mutation with at least 1 first- or second-degree relative with pancreatic cancer
- ECOG Performance Status of 0-1
- No known contraindications to MRI or gadolinium contrast
- Willing to undergo MRI and screening for metal implants or injury
- Estimated glomerular filtration rate (GFR) greater than 29 mL/min
- Ability to provide informed consent
- Willing to return to study site for all assessments
You will not qualify if you...
- Prior history of pancreatic cancer
- Presence of metastatic cancer or cancer requiring adjuvant chemotherapy within the past 5 years
- Received chemotherapy within the past 6 months (hormonal therapy allowed if disease-free for at least 5 years)
- Hereditary pancreatitis
- Estimated glomerular filtration rate (GFR) less than 30 mL/min
- Contraindication to MRI or gadolinium contrast
- Pregnant or nursing women
- Co-morbid illnesses or other diseases judged inappropriate for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nuvance Health
Norwalk, Connecticut, United States, 06856
Actively Recruiting
Research Team
T
Tammy Lo, APRN
CONTACT
P
Pramila Krumholtz, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here