Screening for Pancreatic Cancer in People 50 to 90 Years Old with Strong Family History or Genetic Risk

What this Trial Is About

This research aims to screen for pancreatic cancer and its early signs in people aged 50 and older who have a strong family history or genetic risk for pancreatic cancer. The study focuses on using Magnetic Resonance Imaging and Magnetic cholangiopancreatography MRIMRCP to detect early-stage pancreatic cancer or precursor lesions. Blood samples will also be collected to help develop a blood-based screening test for pancreatic cancer. Participants will undergo annual MRIMRCP with IV gadolinium contrast and high-resolution imaging of the pancreas for up to 3 years, totaling four scans. Blood samples and a brief psychological survey will be collected every six months during this period. If any abnormalities appear on MRI, these will be reviewed by a multi-disciplinary tumor board and discussed with the participant. The study covers all MRI costs. Throughout the study, participants will be asked to complete surveys and provide blood samples for a bio-bank. The research team will monitor findings from MRI scans and blood tests regularly to detect early pancreatic cancer or precursor lesions. The study lasts up to three years and includes ongoing assessments to ensure participants health and safety during this time.

A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals