What is this study trying to find out about pancreatic cancer?

This study is investigating the relationship between new or worsening diabetes and early pancreatic cancer or its precursor lesions. Researchers use MRI scans and blood sample analysis to detect early signs. The goal is to improve early detection methods for pancreatic cancer among individuals with recent diabetes changes.

Who may be eligible for this pancreatic cancer clinical trial?

Adults aged 50 or older with new-onset diabetes diagnosed within the past 12 months or worsening diabetes may be eligible. Participants must be able to undergo MRI, have no known contraindications to MRI or contrast, and provide informed consent. Please review eligibility criteria for more details.

Is there any cost to participate in this pancreatic cancer clinical trial?

Study-related care, including MRI scans, blood tests, and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered during participation.

Actively Recruiting

Age: 50Years +

All Genders

Healthy Volunteers

ID03937453

Pancreatic Cancer Screening Study in People With New-Onset or Worsening Diabetes Mellitus PANDOME Study

Led by Nuvance Health · Updated on 2026-04-13

800

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to explore the link between new-onset or worsening diabetes and the later development of pancreatic cancer. It focuses on individuals over 50 years old who have either been diagnosed with diabetes within the past year or have experienced deteriorating diabetes recently. The study uses Magnetic Resonance Imaging and Magnetic Cholangiopancreatography MRIMRCP to screen for early pancreatic cancer or its precursors, helping to identify risks earlier. Participants will undergo an MRI with contrast at the start of the study. Any abnormalities found will be reviewed by a team of specialists and discussed with the participant. Blood samples will be collected every six months for up to three years to create a bio-bank that supports developing a blood test for pancreatic cancer. Additional MRI scans may be done as needed based on expert recommendations. During the study, participants will complete a brief psychological survey and provide blood samples regularly. Researchers will monitor the presence of early pancreatic cancer or precursor lesions over three years. The study tracks the relative risk of pancreatic cancer among those with new or worsening diabetes. Participants must be willing to undergo MRI screening, provide informed consent, and attend all study visits during this period.

CONDITIONS

Brief Title

A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus

Who Can Participate

Age: 50Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Age of at least 50 years.
Diagnosed with diabetes mellitus within the past 12 months with documented prior normal blood sugar tests or with an elevated HbA1c level.
Transition from pre-diabetes to diabetes within the past 12 months with a significant increase in HbA1c.
Diabetes diagnosed within the past 12 months in individuals with one first-degree relative with diabetes.
Deteriorating diabetes shown by a rise in HbA1c greater than 2% in the past 6 months, confirmed by repeat testing, not linked to weight gain or medication non-compliance.
ECOG Performance Status of 0-1.
No known contraindications to MRI or gadolinium contrast.
Willing to undergo MRI and screening for metal implants or injuries.
Able to provide informed consent.
Willing to attend all study visits.

You will not qualify if you...

Prior history of pancreatic cancer.
Metastatic cancer or cancer requiring chemotherapy within the past 5 years.
Received chemotherapy within the past 6 months (hormonal therapy allowed if disease-free for 5 years).
Hereditary pancreatitis.
Use of high dose glucocorticoid steroids within 3 months of diabetes diagnosis or HbA1c elevation.
Contraindications to MRI or gadolinium contrast.
Pregnant or nursing women.
Other illnesses or conditions that would make participation inappropriate as judged by clinicians.

Research Team

Tammy Lo, MSN

Pramila Krumholtz, MSN

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here