Actively Recruiting
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
Led by Minia University · Updated on 2025-12-02
90
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the pancreaticojejunostomy (PJ) anastomosis and reduce postoperative pancreatic fistula (POPF) rates.
CONDITIONS
Official Title
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing pancreaticoduodenectomy for malignant lesions with curative intent following clinical guidelines
- Soft pancreatic texture
- Main pancreatic duct diameter less than 3 mm
- Informed consent obtained
You will not qualify if you...
- Known allergy to cyanoacrylate or Lipiodol
- Extremely hard or fibrotic pancreas
- Significant pancreatitis affecting the pancreatic remnant
- Active infection at the surgical site
- Uncontrolled bleeding disorders
- Severe medical illnesses making surgery unsafe
- Inoperable cancer with distant metastases
- Unresectable tumors found during diagnostic laparoscopy
- Need for left, central, total pancreatectomy, or palliative surgery
- Pregnant or breastfeeding women
- Serious mental disorders
- Vascular invasion requiring vessel resection
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Liver and GIT hospital , Minia University
Minya, Minya Governorate, Egypt, 61519
Actively Recruiting
Research Team
S
Saleh K Saleh, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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