Actively Recruiting
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
Led by University of Pittsburgh · Updated on 2025-12-22
150
Participants Needed
3
Research Sites
234 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.
CONDITIONS
Official Title
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years of age or older with definite chronic pancreatitis undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for pain management
- Endoscopic therapy includes ERCP with pancreatic duct stone removal, stent placement, and/or stricture dilation, with or without intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL)
- Surgery includes drainage procedures such as Frey and Puestow operations
You will not qualify if you...
- Patients with chronic pain from conditions other than chronic pancreatitis
- Patients under 18 years of age
- Patients who have had endoscopic therapy within the past 12 months
- Patients who have undergone prior pancreatic surgery
- Patients who have planned resective surgical procedures (e.g., Whipple procedure, Total Pancreatectomy)
- Patients with peripheral sensory deficits
- Patients known to be pregnant at the time of study screening
- Women who become pregnant during the study cannot continue P-QST testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Indiana University Medical Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
Johns Hopkins Medical Institutions
Baltimore, Maryland, United States, 21287
Actively Recruiting
3
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
A
Anna Evans Phillips, MD, MS
CONTACT
A
Apsara Mishra
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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